The Ailliance Post-Market Clinical Study

Last updated: February 2, 2026
Sponsor: Medtronic Spinal and Biologics
Overall Status: Active - Recruiting

Phase

N/A

Condition

Spinal Cord Disorders

Spinal Cord Malignancy

Spinal Stenosis

Treatment

Follow-up schedule: pre-operative baseline to index surgery

Follow-up schedule: pre-operative baseline to discharge

Follow-up schedule: pre-operative baseline up to 24-months post-procedure

Clinical Study ID

NCT05856370
MDT22045CSTAIL
  • Ages > 18
  • All Genders

Study Summary

The purpose of this clinical study is to collect performance and safety data for post-market Medtronic devices indicated for cranial and/or spinal indication(s).

Subjects are enrolled and followed postoperatively to 24 months. The Ailliance clinical study is intended to collect data congruous with routine clinical care practices.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Subject provides written informed consent per institution and/or geographicalrequirements.

  2. Subject is intended to receive or be treated with an eligible Medtronic Cranial andSpinal Technology (CST) device(s) (see product appendices), used alone or incombination, for a cranial and/or spinal indication(s).

  3. Subject is at least 18 years of age or minimum legal age as required by localregulations.

  4. Subject agrees to complete all required assessments per the Schedule of Events.

Exclusion

Exclusion Criteria:

  1. Subject is currently enrolled or plans to enroll in concurrent drug/device/biologictrial(s) that may confound this trial's results per investigator assessment (i.e. norequired intervention that could affect interpretation of all-around device safetyand or performance).

  2. Subject who is, or is expected to be, inaccessible for all required follow-upvisits.

  3. Subject with exclusion criteria required by local law.

  4. Subject is considered vulnerable at the time of obtaining consent.

Study Design

Total Participants: 1000
Treatment Group(s): 3
Primary Treatment: Follow-up schedule: pre-operative baseline to index surgery
Phase:
Study Start date:
May 01, 2023
Estimated Completion Date:
May 31, 2031

Connect with a study center

  • Hôpital Roger Salengro

    Lille, 59037
    France

    Site Not Available

  • Hôpital Roger Salengro

    Lille 2998324, 59037
    France

    Active - Recruiting

  • Hospital Vall D'Hebron

    Barcelona, 08035
    Spain

    Site Not Available

  • Hospital Vall D'Hebron

    Barcelona 3128760, 08035
    Spain

    Active - Recruiting

  • Kings College Hospital NHS Foundation Trust

    London 2643743, SE5 9RS
    United Kingdom

    Active - Recruiting

  • University of Arizona

    Tucson, Arizona 85721
    United States

    Site Not Available

  • University of Arizona

    Tucson 5318313, Arizona 5551752 85721
    United States

    Active - Recruiting

  • OrthoArkansas

    Little Rock, Arkansas 72204
    United States

    Site Not Available

  • OrthoArkansas

    Little Rock 4119403, Arkansas 4099753 72204
    United States

    Active - Recruiting

  • University of California Davis Medical Center

    Sacramento, California 95816
    United States

    Site Not Available

  • University of California, San Francisco (UCSF)

    San Francisco, California 94143
    United States

    Site Not Available

  • University of California Davis Medical Center

    Sacramento 5389489, California 5332921 95816
    United States

    Active - Recruiting

  • University of California, San Francisco (UCSF)

    San Francisco 5391959, California 5332921 94143
    United States

    Active - Recruiting

  • Indiana University School of Medicine

    Bloomington, Indiana 47401
    United States

    Site Not Available

  • Indiana Spine Group

    Carmel, Indiana 46032
    United States

    Site Not Available

  • The Orthopaedic Research Foundation (OrthoIndy)

    Indianapolis, Indiana 46278
    United States

    Site Not Available

  • Indiana University School of Medicine

    Bloomington 4254679, Indiana 4921868 47401
    United States

    Active - Recruiting

  • Indiana Spine Group

    Carmel 4255466, Indiana 4921868 46032
    United States

    Active - Recruiting

  • The Orthopaedic Research Foundation (OrthoIndy)

    Indianapolis 4259418, Indiana 4921868 46278
    United States

    Active - Recruiting

  • Norton Leatherman Spine Specialists

    Louisville, Kentucky 40202
    United States

    Site Not Available

  • Norton Leatherman Spine Specialists

    Louisville 4299276, Kentucky 6254925 40202
    United States

    Active - Recruiting

  • University of Maryland Medical Center

    Baltimore, Maryland 21201
    United States

    Site Not Available

  • University of Maryland Medical Center

    Baltimore 4347778, Maryland 4361885 21201
    United States

    Active - Recruiting

  • Michigan Orthopaedic & Spine Surgeons

    Rochester Hills, Michigan 48307
    United States

    Site Not Available

  • Michigan Orthopaedic & Spine Surgeons

    Rochester Hills 5007402, Michigan 5001836 48307
    United States

    Active - Recruiting

  • University of Minnesota

    Minneapolis, Minnesota 55454
    United States

    Site Not Available

  • University of Minnesota

    Minneapolis 5037649, Minnesota 5037779 55454
    United States

    Active - Recruiting

  • Washington University School of Medicine

    Saint Louis, Missouri 63110-1010
    United States

    Site Not Available

  • Washington University School of Medicine

    St Louis 4407066, Missouri 4398678 63110
    United States

    Active - Recruiting

  • University at Buffalo

    Buffalo, New York 14221
    United States

    Site Not Available

  • University at Buffalo

    Buffalo 5110629, New York 5128638 14221
    United States

    Active - Recruiting

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio 43210
    United States

    Site Not Available

  • The Ohio State University Wexner Medical Center

    Columbus 4509177, Ohio 5165418 43210
    United States

    Active - Recruiting

  • University of Pittsburgh Medical Center UPMC Presbyterian

    Pittsburgh, Pennsylvania 15213
    United States

    Site Not Available

  • University of Pittsburgh Medical Center UPMC Presbyterian

    Pittsburgh 5206379, Pennsylvania 6254927 15213
    United States

    Active - Recruiting

  • Rhode Island Hospital University Orthopedic

    Providence, Rhode Island 02914
    United States

    Site Not Available

  • Rhode Island Hospital University Orthopedic

    Providence 5224151, Rhode Island 5224323 02914
    United States

    Active - Recruiting

  • Tennessee Orthopaedic Alliance

    Nashville, Tennessee 37209
    United States

    Site Not Available

  • Tennessee Orthopaedic Alliance

    Nashville 4644585, Tennessee 4662168 37209
    United States

    Active - Recruiting

  • American Neurospine Institute, PLLC

    Frisco, Texas 75033
    United States

    Site Not Available

  • American Neurospine Institute, PLLC

    Frisco 4692559, Texas 4736286 75033
    United States

    Active - Recruiting

  • University of Virginia Health System

    Charlottesville, Virginia 22903
    United States

    Site Not Available

  • Virginia Spine Institute

    Reston, Virginia 20191
    United States

    Site Not Available

  • University of Virginia Health System

    Charlottesville 4752031, Virginia 6254928 22903
    United States

    Active - Recruiting

  • Virginia Spine Institute

    Reston 4781530, Virginia 6254928 20191
    United States

    Active - Recruiting

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