Phase
Condition
Muscular Dystrophy
Treatment
Non-interventional study
Clinical Study ID
Ages > 40 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
DM2 Inclusion Criteria:
Age 40 and older
Diagnosis of DM2 is based on genetic testing and/or clinical criteria. If thediagnosis is based on clinical criteria, positive DM2 genetic testing is required infirst-degree relatives
Symptoms or clinical findings of proximal muscle weakness
Ambulate independently (a cane or walking stick is permitted)
Able to provide informed consent for participation in the study
Exclusion
DM2 and Healthy Control (HC) Exclusion Criteria:
Individuals with a pacemaker, defibrillator, or metal implanted that iscontraindicated for MRI
Individuals who are claustrophobic
Individuals with a prior diagnosis of dementia, seizure, stroke, multiple sclerosis,Parkinson's Disease, or other neurodegenerative diseases
Individuals with active psychiatric illness, alcohol or substance abuse, ordependence
Individuals with a pacemaker, defibrillator, or metal implanted that iscontraindicated for MRI
Individuals who are claustrophobic
Major medical illness which would prevent safe testing of MRI or motor function.
On medications with substantial sedative or cognitive side effects unless the doseshave been stable over the last 3 months before the study visit
pregnancy
Weight > 400 lbs as the subject could not be properly positioned on the MRI table
Inability or unwillingness to give written informed consent
For participants who undergo lumbar puncture procedure: Use of anti-plateletmedications within 7 days, use of anticoagulants such as warfarin (Coumadin),history of a bleeding disorders, evidence of platelet count < 150,000 within thelast 6 months, or have hardware (i.e., pins, screws, rods, etc.) in the lower backarea
Healthy Control (HC) Inclusion Criteria:
Age 40 and older
Ambulate independently
Able to provide informed consent for participation in the study
Study Design
Study Description
Connect with a study center
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157
United StatesActive - Recruiting


Not the study for you?
Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.