Effect of Multimodal Prehabilitation After Colorectal Cancer Surgery

Last updated: May 10, 2023
Sponsor: Xiamen University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Colon Cancer; Rectal Cancer

Cancer

Colorectal Cancer

Treatment

Multimodal prehabilitation management Multimodal prehabilitation management

Clinical Study ID

NCT05854394
NCT20211154469
  • Ages 18-75
  • All Genders

Study Summary

The process of enhancing an individual's functional capacity to optimize physiologic reserves before an operation to withstand the stress of surgery has been coined prehabilitation. This is a prospective randomized controlled trail, designed to explore if the patients who take Colorectal Cancer Surgery will benefit from short-term multimodal prehabilitation strategy. multimodal prehabilitation includes exercise, nutrition supplement and physiology management preoperatively. It starts from the day that patients decide to take the surgery until the day before surgery, lasting 1~2 week in The First Affiliated Hospital of Xiamen University. And investigators follow-up patients until 4 weeks after surgery to investigate if multimodal prehabilitation strategy can improve the postoperative functional recovery and improve the quality of life #reduce complications and improve prognosis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • From 18 y/o to 75 y/o
  • Suspected of colorectal cancer
  • Decide to take the colorectal cancer radical surgery in The First Hospital Affiliatedto Xiamen University
  • Patients with post-operative pathological diagnosis of colorectal cancer

Exclusion

Exclusion Criteria:

  • Refuse or fail to cooperate the study (due to any reason)
  • Unable to tolerate prehabilitaion strategy (including exercise guide, whey protein andpsycho-relaxation exercise)
  • Other severe cardio-pulmonary diseases that would affect the 6MWD

Study Design

Total Participants: 100
Treatment Group(s): 1
Primary Treatment: Multimodal prehabilitation management Multimodal prehabilitation management
Phase:
Study Start date:
April 01, 2023
Estimated Completion Date:
December 31, 2023

Study Description

The process of enhancing an individual's functional capacity to optimize physiologic reserves before an operation to withstand the stress of surgery has been coined prehabilitation. It has been confirm that trimodal prehabilitation strategy including exercise, diet and psychology guidance could improve postoperative functional recovery after surgery for patients undergoing colorectal resection. Although many clinical studies have confirmed that preoperative exercise for patients undergoing colorectal cancer surgery is safe and useful, but the prehabilitation strategy in previous studies usually takes 48 weeks. However, patient suspected of malignant tumor often wouldn't wait for such a long period. Investigators therefore designed this study to investigate if a 12 week multimodal prehabilitation strategy benefits the patients undergoing laparoscopic colorectal cancer resection. There will be 100 patients awaiting operation for primary colorectal cancer recruited in this research at The First Affiliated Hospital of Xiamen University.

After informed consent was obtained, the patients will be divided into two groups randomly, the prehibilitation group and control group.

The prehabilitation group will receive an individual trimodal prehabilitation strategy after a complete assessment, including physical exercise, nutritional optimization, and psychological therapy, as well as conventional guidance. The length of prehabilitation was determined by the waiting time till surgery alone. The control group will receive the conventional guidance, including drug treatment recommendations for chronic disease, quit smoking and abstinence. Both of the groups are also provided some useful information about surgery process. The functional capability will be examined for both groups at several time points (baseline, the day before surgery,4 weeks postoperatively) The primary end point is functional walking capacity as measured by the 6 minutes walking distance (6MWD) 4 weeks postoperatively, health-related quality of life scales and cancer-related fatigue. The secondary end points include self-reported physical activity, and prognosis information (postoperative complications, length of hospital stay, ICU stay time, hospitalization expenses, etc.).

Connect with a study center

  • The First Affiliated Hospital of Xiamen University

    Xiamen, FuJian Provice 361000
    China

    Active - Recruiting

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