RUFUS - Group Rumination-focused CBT for Negative Symptoms

Last updated: October 20, 2023
Sponsor: Mental Health Services in the Capital Region, Denmark
Overall Status: Active - Recruiting

Phase

N/A

Condition

Schizophrenia And Schizoaffective Disorders (Pediatric)

Schizotypal Personality Disorder (Spd)

Treatment

group rumination focused cognitive behavioural therapy

Treatment as usual

Clinical Study ID

NCT05851950
05851950
  • Ages 18-37
  • All Genders

Study Summary

Abstract - --

Introduction:

Psychosis spectrum disorders are characterized by both positive and negative symptoms, but whereas there is good effect of treatment on positive symptoms, there is still a scarcity of effective interventions aimed at reducing negative symptoms. Rumination has been proposed as an important and fundamental factor in the development and maintenance of symptoms across psychiatric diagnoses, and there is a need to develop effective interventions targeting rumination behaviors and negative symptoms in patients with psychotic disorders. The aim of the current study is to investigate the feasibility and acceptability of group rumination-focused cognitive behavioral therapy (RFCBT) in the treatment of young people with psychosis spectrum disorders as well as investigating potential indications of treatment efficacy.

Methods and analysis: The study is a mixed-method clinical randomized controlled pilot trial with a target sample of 60 patients, who are randomized to either receive 13 weeks of group CFCBT or 13 weeks of treatment as usual (TAU). All patients are examined at the start of the project and at the 13-week follow-up. The researcher will compare changes in outcomes from baseline to posttreatment between group CFCBT and TAU. In addition, qualitative analyzes are carried out to explore feasibility and acceptability and to uncover the patients' experience of receiving the intervention.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Diagnosed with a psychosis spectrum disorder (ICD-10 F2x)
  2. At least 8 months left of their OPUS treatment
  3. The presence of rumination behavior as assessed by a score of minimum 30 on thePerseverative Thinking Questionnaire (PTQ)
  4. Danish-speaking

Exclusion

Exclusion Criteria:

  1. Substance abuse or positive symptoms that make participation in therapy difficult
  2. Severe suicidal thoughts/behavior
  3. Lacks capacity to consent
  4. Mild, moderate, or severe intellectual disability (IQ ˂ 70)
  5. Planned adjustment of antidepressant and/or antipsychotic treatment (noted in thepatient's medical record)

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: group rumination focused cognitive behavioural therapy
Phase:
Study Start date:
August 01, 2023
Estimated Completion Date:
July 01, 2026

Connect with a study center

  • Mental Health Centre Copenhagen

    Copenhagen,
    Denmark

    Active - Recruiting

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