AZD0120 in Relapsed/Refractory Multiple Myeloma (DURGA-1)

Inclusion Criteria:

• ≥18 years of age at the time of consent.

• ECOG performance status of 0 or 1.

• Documented diagnosis of MM per IMWG diagnostic criteria.

• Participant must have received at least 3 prior lines of therapy, which include a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and an anti-CD38 antibody.

• Have documented evidence of progressive disease per IMWG criteria.

• Participant must have measurable disease at screening.

• Participant must have adequate bone marrow and organ function (hematological, hepatic and renal) demonstrated at screening.

Exclusion Criteria :

• Participant has a history of significant toxicity during prior CAR T-cell therapy and T-cell engaging therapy.

• Participant has a history of a prior non-hematologic malignancy, unless the participant has been disease-free with no evidence of recurrence for ≥ 2 years. Some exceptions may apply.

• Participant has significant cardiac, neurological, or psychiatric conditions.

• Any other significant medical conditions such as:

• Serious active or uncontrolled infection

• Active autoimmune disease or a history of autoimmune disease within 2 years

• Active plasma cell leukemia at the time of screening

• Clinical evidence of dementia or altered mental status, or stroke, intracranial haemorrhage, or seizure within 6 months before signing informed consent form (ICF).

• Known active or prior history of central nervous system involvement or exhibits clinical signs of meningeal involvement of MM.

Other protocol-defined Inclusion/Exclusion criteria apply.