Phase
Condition
Arrhythmia
Atrial Fibrillation
Dysrhythmia
Treatment
Sampling
Clinical Study ID
Ages 18-85 All Genders
Study Summary
Eligibility Criteria
Inclusion
Group 1 - Study Inclusion criteria
Age between 18 and 85 years old
Permanent or persistent AFib for which the patient undergoes ablation surgery surgery of atrial fibrillation with isolated radiofrequency or associated with possible correction of heart valve disease with or without coronary artery disease Exclusion criteria
Age < 18 years
Need for emergency cardiac surgery
Presence of concomitant systemic inflammatory diseases
Group 2 - Control Inclusion criteria
Age between 18 and 85 years old
Sinus rhythm at the time of admission for surgery
No AFib in history
Hospitalized for correction of isolated mitral valve disease or associated with correction of other valve diseases Exclusion criteria
Age < 18 years
Need for surgical coronary revascularization
Need for emergency cardiac surgery
Presence of concomitant systemic inflammatory diseases
Group 3 - Autoptic control Inclusion criteria
Age between 18 and 85 years old Exclusion criteria
No signs of post-mortal tissue decomposition assessed by histological examination
Documented history of arrhythmias, valvular dysfunction, atherosclerosis of the coronary arteries, previous myocardial infarctions, foci of myocardial fibrosis greater than 2 mm on histology, presence of inflammatory cells in the interstitium, sarcoidosis, amyloidosis, chronic inflammatory lung diseases and connective tissue diseases.
Study Design
Connect with a study center
IRCCS Ospedale San Raffaele
Milan, 20132
ItalyActive - Recruiting
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