Pitolisant Effects on Affect and Cognition Exploratory Study (PEACE Study)

Inclusion Criteria:

• Participant is willing and able to give informed consent for participation in theresearch

• Not currently taking any medications which may interfere with pitolisant, includingpsychoactive medications

• Not currently using antihistaminergic medication

• Aged 18-45 years

• Male or female

• Sufficiently fluent English to understand and complete cognitive tasks andquestionnaires

• Body Mass Index above or below 18-30

• Right handed

Exclusion Criteria:

• Current pregnancy (as determined by urine pregnancy test taken during screeningvisit), planning to become pregnant or breast feeding

• Any past or current history of severe and/or serious psychiatric disorder, includingbut not limited to schizophrenia, psychosis, bipolar affective disorder, majordepressive disorder, obsessive compulsive disorder

• Clinically significant abnormal values for urine drug screen, blood pressuremeasurement ( in accordance with AP20 'non-invasive blood pressure') and ECG. Aparticipant with a clinical abnormality or parameters outside the reference rangefor the population being studied may be included only if the Investigator considersthat the finding is unlikely to introduce additional risk factors and will notinterfere with the study procedures

• History of, or current medical conditions which, in the opinion of the investigator,may interfere with the safety of the participant or the scientific integrity of thestudy, including epilepsy/seizures, brain injury, hepatic or renal disease,acid-related gastro-intestinal problems, Central Nervous System (CNS) tumours,neurological conditions

• Current or past history of drug or alcohol dependency

• Severe lactose intolerance

• Use of recreational drugs (e.g. cannabis, cocaine, amphetamines) within past 3months

• Participation in a study which uses the same computer tasks as those in the presentstudy (determined by asking participants about previous studies participated induring screening) within past 3 months

• Participation in a study that involves the use of a medication within the last threemonths

• Smoking > 5 cigarettes per day

• Consumption of a high amount of caffeine per day (> 400ml caffeine) (e.g., 5 or morecups of coffee)

• Participant is unlikely to comply with the clinical study protocol or is unsuitablefor any other reason, in the opinion of the Investigator

• Any contraindication to MRI scanning (e.g. metal objects inside the body,pacemakers, significant claustrophobia)

• Not right handed