Gastroparesis Registry 4

Inclusion Criteria:

• Age at least 18 years at initial screening visit

• Symptoms of Gp and/or FD of at least 12-weeks duration with varying degrees ofnausea, vomiting, early satiety, postprandial fullness, abdominal pain, abdominalburning. Thus, patients can enter the GpR4 registry primarily with abdominal painsuggesting FD-Epigastric Pain Syndrome.

• Successful completion of gastric emptying scintigraphy of solids using the 4-hourEgg Beaters® protocol (or equivalent generic liquid egg white meal) within the last 6 months

• Negative upper endoscopy or upper radiographic GI series within 2 years ofregistration

Exclusion Criteria:

• Use of narcotic analgesics greater than three days per week

• Presence of other conditions that could explain the patient's symptoms such as:

• Pyloric or intestinal obstruction as evidenced by EGD, UGI, or Abdominal CT

• Active inflammatory bowel disease

• Known eosinophilic gastroenteritis or eosinophilic esophagitis

• Primary neurological conditions that can cause nausea and vomiting such as increasedintracranial pressure, space occupying or inflammatory/infectious lesions

• Acute or chronic renal failure (serum creatinine >3 mg/dL) and/or on hemodialysis orperitoneal dialysis

• Acute liver failure or advanced liver disease (Child's B or C; a Child-Pugh-Turcotte (CPT) score of ≥7)

• Pancreatic disorder if present on pancreatic imaging or pancreatic function testing

• Prior gastric surgery including total or subtotal (near complete) gastric resection,esophagectomy, gastrojejunostomy, gastric bypass, gastric sleeve, pyloroplasty,pyloromyotomy, or any fundoplication (Nissen, Tor)

• Any other condition, which in the opinion of the investigator, could explain thesymptoms or interfere with study requirements

• Females who are pregnant. A urine pregnancy test is routinely obtained on allfemales immediately prior to gastric emptying procedures.

• Inability to comply with or complete the gastric emptying scintigraphy test (including allergy to eggs)

• Inability to obtain informed consent