Chronic Thromboembolic Disease Registry

Last updated: June 9, 2025
Sponsor: University of California, San Francisco
Overall Status: Active - Recruiting

Phase

N/A

Condition

Thromboembolism

Treatment

Survey

Clinical Study ID

NCT05843500
23-38534
  • Ages > 18
  • All Genders

Study Summary

The goal of this patient registry is to learn about the natural history in patients with chronic thromboembolic disease (CTD) and/or chronic thromboembolic pulmonary hypertension (CTEPH). The main question[s] it aims to answer are:

  • Long-term outcome after various types of treatment, including medication, balloon pulmonary angioplasty, and pulmonary endarterectomy

  • Effect of treatment on patient's quality of life and exercise tolerance Participants will be followed longitudinally to assess their health outcomes and quality of life via chart review and health quality surveys.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients referred with CTED and/or CTEPH defined as:

  1. Mean pulmonary arterial pressure (mPAP) > 20 mmHg at rest with pulmonaryvascular resistance (PVR) > 2 Wood units (WU); or if mPAP ≤ 20 mmHg or PVR ≤ 2WU at rest, have exercise limitations from chronic thromboembolic pulmonarydisease (CTEPD) without pulmonary hypertension (PH)

  2. Radiologic finding of chronic thromboembolic disease, including abnormalventilation perfusion scan, pulmonary angiogram, computer tomographic pulmonaryangiogram, or magnetic resonance pulmonary angiogram

  3. Post-embolic exercise intolerance and evidence of chronic thromboembolicdisease in the absence of resting pulmonary hypertension

  • Treatment with anticoagulation for ≥ 3 months before diagnosis of CTEPH or CTEPDwithout PH

  • Age ≥ 18 years

Exclusion

Exclusion Criteria:

  • Main cause of PH other than World Health Organization (WHO) group 4 (CTEPH)

  • Patient's refusal to participate in clinical research and/or receive intervention

Study Design

Total Participants: 100
Treatment Group(s): 1
Primary Treatment: Survey
Phase:
Study Start date:
August 01, 2023
Estimated Completion Date:
July 01, 2028

Connect with a study center

  • University of California San Francisco

    San Francisco, California 94143
    United States

    Active - Recruiting

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