Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy

Last updated: April 30, 2025
Sponsor: Ludwig-Maximilians - University of Munich
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

PARTNER intervention

Control intervention

Clinical Study ID

NCT05842928
01VSF21038
  • Ages > 65
  • All Genders

Study Summary

The PARTNER study is a multicentre, two-arm, pragmatic cluster-randomised trial evaluating the impact of a focused and patient-centred cooperation between general practitioners (GPs) and community pharmacists (PARTNER intervention) on reductions in the use of psychotropic, sedative and anticholinergic potentially inappropriate medication (PSA-PIM) compared to a control intervention. The PARTNER intervention comprises (1) education for health care professionals, (2) an interprofessional workshop and case conference, (3) a pharmacy visit with brown bag/medication review and patient empowerment, (4) GP practice visit with shared decision making. The control intervention only comprises a pharmacy visit with brown bag review.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 65 years or older

  • Patient is capable of giving consent

  • GP contact in the quarter prior to inclusion

  • Current use of ≥ 5 drugs, including ≥ 1 PSA-PIM (hypnotics, opioids, gabapentinoids,antipsychotics, antidepressants, anticholinergic urospasmolytics) with a treatmentduration of ≥ 6 months

  • Willingness to select a regular pharmacy for the study period

  • Consent to data exchange between GP and community pharmacy

Exclusion

Exclusion Criteria:

  • Terminal illness (life expectancy < 6 months)

  • Current treatment of pain associated with cancer

  • Other serious physical illness or mental distress (e.g. bereavement) that makesparticipation in the study impossible (according to the GP's assessment)

  • Psychiatric illness or addiction that makes participation in the study impossible (according to the GP's assessment)

  • Unable to meet the requirements of the study (participation in telephone or writtenquestionnaires, visits to the GP practice or community pharmacy, alone or with thehelp of caregivers for physical infirmity)

  • Current participation in research projects on medication safety or geriatricmedicine

Study Design

Total Participants: 352
Treatment Group(s): 2
Primary Treatment: PARTNER intervention
Phase:
Study Start date:
March 25, 2023
Estimated Completion Date:
October 31, 2026

Connect with a study center

  • University of Bielefeld

    Bielefeld, 33615
    Germany

    Site Not Available

  • University Hospital, LMU Munich

    Munich, 80336
    Germany

    Active - Recruiting

  • Witten/Herdecke University

    Witten, 58448
    Germany

    Site Not Available

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