Study of Two Digital Therapeutics for the Treatment of Experiential Negative Symptoms of Schizophrenia

Last updated: October 14, 2025
Sponsor: Click Therapeutics, Inc.
Overall Status: Completed

Phase

3

Condition

Tourette's Syndrome

Psychosis

Mood Disorders

Treatment

Digital Therapeutic

Clinical Study ID

NCT05838625
CT-155-R-001
  • Ages > 18
  • All Genders

Study Summary

This study evaluates the efficacy of two prescription digital therapeutics (PDT) in addition to standard of care (SOC) therapy for the treatment of experiential negative symptoms of schizophrenia in late adolescents and adults.

Eligibility Criteria

Inclusion

Inclusion Criteria:

A participant will be eligible for entry into the study if all of the following criteria are met:

  1. Has a primary diagnosis of schizophrenia.

  2. Is on a stable dose of antipsychotic medication(s).

  3. Has obtained an average score of ≥2 (moderate to severe) in at least two of thethree CAINS-MAP domains (Social, Work, or Recreational).

Exclusion

Exclusion Criteria:

A participant will not be eligible for study entry if any of the following criteria are met:

  1. Is currently treated with more than two antipsychotic medications (including morethan two dosage forms).

  2. Meets DSM-5, for diagnoses not under investigation.

  3. Has participated in a CT-155 clinical study.

Study Design

Total Participants: 464
Treatment Group(s): 1
Primary Treatment: Digital Therapeutic
Phase: 3
Study Start date:
March 31, 2023
Estimated Completion Date:
July 23, 2025

Study Description

The purpose of the proposed study is to evaluate the efficacy and safety of two prescription digital therapeutics as an adjunct treatment to SOC in participants 18 years of age or older diagnosed with experiential negative symptoms of schizophrenia.

Connect with a study center

  • Investigational center

    Chandler, Arizona 85226
    United States

    Site Not Available

  • Investigational center 461

    Chandler, Arizona 85226
    United States

    Active - Recruiting

  • Investigational center

    Phoenix, Arizona 85012
    United States

    Site Not Available

  • Investigational center 439

    Phoenix, Arizona 85012
    United States

    Active - Recruiting

  • Investigational center

    Chandler 5289282, Arizona 5551752 85226
    United States

    Site Not Available

  • Investigational center

    Phoenix 5308655, Arizona 5551752 85012
    United States

    Site Not Available

  • Investigational center

    Anaheim, California 92805
    United States

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  • Investigational center 401

    Anaheim, California 92805
    United States

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  • Investigational center

    Culver City, California 90230
    United States

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  • Investigational center 411

    Culver City, California 90230
    United States

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  • Investigational center

    Garden Grove, California 92845
    United States

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  • Investigational center 413

    Garden Grove, California 92845
    United States

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  • Investigational center

    La Habra, California 90631
    United States

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  • Investigational center 421

    La Habra, California 90631
    United States

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  • Investigational center

    Long Beach, California 90807
    United States

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  • Investigational center 409

    Long Beach, California 90807
    United States

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  • Investigational center

    Los Angeles, California 90025
    United States

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  • Investigational center 479

    Los Angeles, California 90025
    United States

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    Newport Beach, California 92660
    United States

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  • Investigational center 483

    Newport Beach, California 92660
    United States

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    Oceanside, California 92056
    United States

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  • Investigational center 431

    Oceanside, California 92056
    United States

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    Orange, California 92868
    United States

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    Orange, California 92868
    United States

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    San Bernardino, California 92408
    United States

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    San Bernardino, California 92408
    United States

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    Torrance, California 90504
    United States

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  • Investigational center 407

    Torrance, California 90504
    United States

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  • Investigational center

    Anaheim 5323810, California 5332921 92805
    United States

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    Culver City 5341114, California 5332921 90230
    United States

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    Garden Grove 5351515, California 5332921 92845
    United States

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    La Habra 5363922, California 5332921 90631
    United States

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    Long Beach 5367929, California 5332921 90807
    United States

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    Los Angeles 5368361, California 5332921 90025
    United States

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    Newport Beach 5376890, California 5332921 92660
    United States

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    Oceanside 5378771, California 5332921 92056
    United States

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    Orange 5379513, California 5332921 92868
    United States

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    San Bernardino 5391710, California 5332921 92408
    United States

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    Torrance 5403022, California 5332921 90504
    United States

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    Cromwell, Connecticut 06416
    United States

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  • Investigational center 446

    Cromwell, Connecticut 06416
    United States

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    Hartford, Connecticut 06116
    United States

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    Hartford, Connecticut 06116
    United States

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    Cromwell 4832121, Connecticut 4831725 06416
    United States

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    Hartford 4835797, Connecticut 4831725 06116
    United States

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    Hialeah, Florida 33016
    United States

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    Hialeah, Florida 33016
    United States

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    Largo, Florida 33777
    United States

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    Largo, Florida 33777
    United States

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    Miami, Florida 33156
    United States

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    Miami, Florida 33156
    United States

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    Miami, Florida 33155
    United States

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  • Investigational center 464

    Miami, Florida 33122
    United States

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    Miami, Florida 33145
    United States

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    Miami, Florida 33133
    United States

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    Miami Lakes, Florida 33014
    United States

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    Miami Lakes, Florida 33014
    United States

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    Orlando, Florida 32803
    United States

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    Orlando, Florida 32803
    United States

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    Orlando, Florida 32803
    United States

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    West Palm Beach, Florida 33407
    United States

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    West Palm Beach, Florida 33407
    United States

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    Hialeah 4158476, Florida 4155751 33016
    United States

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    Largo 4161580, Florida 4155751 33777
    United States

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    Miami 4164138, Florida 4155751 33156
    United States

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    Miami Lakes 4164186, Florida 4155751 33014
    United States

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    Orlando 4167147, Florida 4155751 32803
    United States

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    West Palm Beach 4177887, Florida 4155751 33407
    United States

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    Atlanta, Georgia 30338
    United States

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    Atlanta, Georgia 30338
    United States

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    Atlanta, Georgia 30318
    United States

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    Atlanta, Georgia 30328
    United States

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    Atlanta, Georgia 30328
    United States

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    Augusta, Georgia 30912
    United States

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    Augusta, Georgia 30912
    United States

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    Atlanta 4180439, Georgia 4197000 30338
    United States

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    Augusta 4180531, Georgia 4197000 30912
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    Chicago, Illinois 60611
    United States

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    Chicago, Illinois 60611
    United States

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    Chicago, Illinois 60622
    United States

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    Springfield, Illinois 77030
    United States

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    Springfield, Illinois 77030
    United States

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    Warrenville, Illinois 60555
    United States

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    Warrenville, Illinois 60555
    United States

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  • Investigational center

    Chicago 4887398, Illinois 4896861 60611
    United States

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    Springfield 4250542, Illinois 4896861 77030
    United States

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  • Investigational center

    Warrenville 4915525, Illinois 4896861 60555
    United States

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    Marrero, Louisiana 70072
    United States

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  • Investigational center 465

    Marrero, Louisiana 70072
    United States

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  • Investigational center

    Marrero 4332628, Louisiana 4331987 70072
    United States

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    Baltimore, Maryland 21204
    United States

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  • Investigational center 472

    Baltimore, Maryland 21204
    United States

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    Baltimore 4347778, Maryland 4361885 21204
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  • Investigational center

    Boston, Massachusetts 02131
    United States

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  • Investigational center 455

    Boston, Massachusetts 02131
    United States

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  • Investigational center

    Boston 4930956, Massachusetts 6254926 02131
    United States

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  • Investigational center

    Flowood, Mississippi 39232
    United States

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  • Investigational center 417

    Flowood, Mississippi 39232
    United States

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  • Investigational center

    Flowood 4426822, Mississippi 4436296 39232
    United States

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  • Investigational center

    Saint Louis, Missouri 63141
    United States

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  • Investigational center 482

    Saint Louis, Missouri 63141
    United States

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  • Investigational center

    St. Louis, Missouri 63141
    United States

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  • Investigational center

    St Louis 4407066, Missouri 4398678 63141
    United States

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  • Investigational center

    Omaha, Nebraska 68144
    United States

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  • Investigational center 468

    Omaha, Nebraska 68144
    United States

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  • Investigational center

    Omaha 5074472, Nebraska 5073708 68144
    United States

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  • Investigational center

    Las Vegas, Nevada 89124
    United States

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  • Investigational center 438

    Las Vegas, Nevada 89124
    United States

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  • Investigational center

    Las Vegas 5506956, Nevada 5509151 89124
    United States

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  • Investigational center

    Marlton, New Jersey 08054
    United States

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  • Investigational center 430

    Marlton, New Jersey 08054
    United States

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  • Investigational center

    Marlton 4502911, New Jersey 5101760 08054
    United States

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  • Investigational center

    Cedarhurst, New York 11516
    United States

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  • Investigational center 467

    Cedarhurst, New York 11516
    United States

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    Glen Oaks, New York 11004
    United States

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  • Investigational center 426

    Glen Oaks, New York 11004
    United States

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  • Click Therapeutics

    New York, New York 10013
    United States

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  • Investigational center

    New York, New York 10027
    United States

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  • Investigational center 400

    New York, New York 10027
    United States

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    New York, New York 10032
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    New York, New York 10029
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  • Investigational center

    Rochester, New York 14623
    United States

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  • Investigational center 460

    Rochester, New York 14623
    United States

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  • Investigational center

    Cedarhurst 5111974, New York 5128638 11516
    United States

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  • Investigational center

    Glen Oaks 5118650, New York 5128638 11004
    United States

    Site Not Available

  • Click Therapeutics

    New York 5128581, New York 5128638 10013
    United States

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  • Investigational center

    New York 5128581, New York 5128638 10027
    United States

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  • Investigational center

    Rochester 5134086, New York 5128638 14623
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  • Investigational center

    Charlotte, North Carolina 27608
    United States

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  • Investigational center 433

    Charlotte, North Carolina 27608
    United States

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  • Investigational center 434

    Charlotte, North Carolina 28211
    United States

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  • Investigational center 486

    Charlotte, North Carolina 28226
    United States

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    Charlotte 4460243, North Carolina 4482348 27608
    United States

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    Beachwood, Ohio 44122
    United States

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  • Investigational center 412

    Beachwood, Ohio 44122
    United States

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    Cincinatti, Ohio 45267
    United States

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    Cincinnati, Ohio 45267
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    Cincinnati, Ohio 45267
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    Columbus, Ohio 43210
    United States

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  • Investigational center 428

    Columbus, Ohio 43210
    United States

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    Beachwood 5146711, Ohio 5165418 44122
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    Cincinnati 4508722, Ohio 5165418 45267
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    Columbus 4509177, Ohio 5165418 43210
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    Oklahoma City, Oklahoma 73116
    United States

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  • Investigational center 440

    Oklahoma City, Oklahoma 73116
    United States

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    Oklahoma City 4544349, Oklahoma 4544379 73116
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    State College, Pennsylvania 16801
    United States

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  • Investigational center 484

    State College, Pennsylvania 16801
    United States

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  • Investigational center

    State College 5213681, Pennsylvania 6254927 16801
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    Charleston, South Carolina 29425
    United States

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    Charleston, South Carolina 29425
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    Charleston 4574324, South Carolina 4597040 29425
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    Austin, Texas 78752
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    Austin, Texas 78752
    United States

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    Fort Worth, Texas 76104
    United States

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    Fort Worth, Texas 76104
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    Houston, Texas 77030
    United States

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    Houston, Texas 77030
    United States

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  • Investigational center 447

    Houston, Texas 77081
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  • Investigational center 448

    Houston, Texas 77055
    United States

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  • Investigational center 473

    Houston, Texas 77088
    United States

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  • Investigational center 478

    Houston, Texas 77077
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    Irving, Texas 75062
    United States

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    Irving, Texas 75062
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    Mesquite, Texas 75149
    United States

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    Mesquite, Texas 75149
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    Plano, Texas 75093
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  • Investigational center 452

    Plano, Texas 75093
    United States

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  • Investigational center

    Austin 4671654, Texas 4736286 78752
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    Forth Worth, Texas 4736286 76104
    United States

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    Houston 4699066, Texas 4736286 77030
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    Irving 4700168, Texas 4736286 75062
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    Mesquite 4710826, Texas 4736286 75149
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    Plano 4719457, Texas 4736286 75093
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    Saint George, Utah 84770
    United States

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    Saint George, Utah 84770
    United States

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    Salt Lake City, Utah 84105
    United States

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  • Investigational center 480

    Salt Lake City, Utah 84105
    United States

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  • Investigational center

    St. George, Utah 84770
    United States

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  • Investigational center

    Salt Lake City 5780993, Utah 5549030 84105
    United States

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  • Investigational center

    St. George 5546220, Utah 5549030 84770
    United States

    Site Not Available

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