Study of Two Digital Therapeutics for the Treatment of Experiential Negative Symptoms of Schizophrenia

Last updated: January 22, 2025
Sponsor: Click Therapeutics, Inc.
Overall Status: Active - Not Recruiting

Phase

3

Condition

Tourette's Syndrome

Psychosis

Mood Disorders

Treatment

Digital Therapeutic

Clinical Study ID

NCT05838625
CT-155-R-001
  • Ages > 18
  • All Genders

Study Summary

This study evaluates the efficacy of two prescription digital therapeutics (PDT) in addition to standard of care (SOC) therapy for the treatment of experiential negative symptoms of schizophrenia in late adolescents and adults.

Eligibility Criteria

Inclusion

Inclusion Criteria:

A participant will be eligible for entry into the study if all of the following criteria are met:

  1. Has a primary diagnosis of schizophrenia.

  2. Is on a stable dose of antipsychotic medication(s).

  3. Has obtained an average score of ≥2 (moderate to severe) in at least two of thethree CAINS-MAP domains (Social, Work, or Recreational).

Exclusion

Exclusion Criteria:

A participant will not be eligible for study entry if any of the following criteria are met:

  1. Is currently treated with more than two antipsychotic medications (including morethan two dosage forms).

  2. Meets DSM-5, for diagnoses not under investigation.

  3. Has participated in a CT-155 clinical study.

Study Design

Total Participants: 432
Treatment Group(s): 1
Primary Treatment: Digital Therapeutic
Phase: 3
Study Start date:
March 31, 2023
Estimated Completion Date:
July 18, 2025

Study Description

The purpose of the proposed study is to evaluate the efficacy and safety of two prescription digital therapeutics as an adjunct treatment to SOC in participants 18 years of age or older diagnosed with experiential negative symptoms of schizophrenia.

Connect with a study center

  • Investigational center

    Chandler, Arizona 85226
    United States

    Site Not Available

  • Investigational center 461

    Chandler, Arizona 85226
    United States

    Active - Recruiting

  • Investigational center

    Phoenix, Arizona 85012
    United States

    Site Not Available

  • Investigational center 439

    Phoenix, Arizona 85012
    United States

    Active - Recruiting

  • Investigational center

    Anaheim, California 92805
    United States

    Site Not Available

  • Investigational center 401

    Anaheim, California 92805
    United States

    Active - Recruiting

  • Investigational center

    Culver City, California 90230
    United States

    Site Not Available

  • Investigational center 411

    Culver City, California 90230
    United States

    Active - Recruiting

  • Investigational center

    Garden Grove, California 92845
    United States

    Site Not Available

  • Investigational center 413

    Garden Grove, California 92845
    United States

    Active - Recruiting

  • Investigational center

    La Habra, California 90631
    United States

    Site Not Available

  • Investigational center 421

    La Habra, California 90631
    United States

    Active - Recruiting

  • Investigational center

    Long Beach, California 90807
    United States

    Site Not Available

  • Investigational center 409

    Long Beach, California 90807
    United States

    Active - Recruiting

  • Investigational center

    Los Angeles, California 90025
    United States

    Site Not Available

  • Investigational center 479

    Los Angeles, California 90025
    United States

    Active - Recruiting

  • Investigational center

    Newport Beach, California 92660
    United States

    Site Not Available

  • Investigational center 483

    Newport Beach, California 92660
    United States

    Active - Recruiting

  • Investigational center

    Oceanside, California 92056
    United States

    Site Not Available

  • Investigational center 431

    Oceanside, California 92056
    United States

    Active - Recruiting

  • Investigational center

    Orange, California 92868
    United States

    Site Not Available

  • Investigational center 420

    Orange, California 92868
    United States

    Active - Recruiting

  • Investigational center

    San Bernardino, California 92408
    United States

    Site Not Available

  • Investigational center 406

    San Bernardino, California 92408
    United States

    Active - Recruiting

  • Investigational center

    Torrance, California 90504
    United States

    Site Not Available

  • Investigational center 407

    Torrance, California 90504
    United States

    Active - Recruiting

  • Investigational center

    Cromwell, Connecticut 06416
    United States

    Site Not Available

  • Investigational center 446

    Cromwell, Connecticut 06416
    United States

    Active - Recruiting

  • Investigational center

    Hartford, Connecticut 06116
    United States

    Site Not Available

  • Investigational center 449

    Hartford, Connecticut 06116
    United States

    Active - Recruiting

  • Investigational center

    Hialeah, Florida 33016
    United States

    Site Not Available

  • Investigational center 414

    Hialeah, Florida 33016
    United States

    Active - Recruiting

  • Investigational center

    Largo, Florida 33777
    United States

    Site Not Available

  • Investigational center 474

    Largo, Florida 33777
    United States

    Active - Recruiting

  • Investigational center

    Miami, Florida 33156
    United States

    Site Not Available

  • Investigational center 459

    Miami, Florida 33156
    United States

    Active - Recruiting

  • Investigational center 463

    Miami, Florida 33155
    United States

    Active - Recruiting

  • Investigational center 464

    Miami, Florida 33122
    United States

    Active - Recruiting

  • Investigational center 471

    Miami, Florida 33145
    United States

    Active - Recruiting

  • Investigational center 481

    Miami, Florida 33133
    United States

    Active - Recruiting

  • Investigational center

    Miami Lakes, Florida 33014
    United States

    Site Not Available

  • Investigational center 408

    Miami Lakes, Florida 33014
    United States

    Active - Recruiting

  • Investigational center

    Orlando, Florida 32803
    United States

    Site Not Available

  • Investigational center 466

    Orlando, Florida 32803
    United States

    Active - Recruiting

  • Investigational center 477

    Orlando, Florida 32803
    United States

    Active - Recruiting

  • Investigational center

    West Palm Beach, Florida 33407
    United States

    Site Not Available

  • Investigational center 475

    West Palm Beach, Florida 33407
    United States

    Active - Recruiting

  • Investigational center

    Atlanta, Georgia 30338
    United States

    Site Not Available

  • Investigational center 429

    Atlanta, Georgia 30338
    United States

    Active - Recruiting

  • Investigational center 454

    Atlanta, Georgia 30318
    United States

    Active - Recruiting

  • Investigational center 476

    Atlanta, Georgia 30328
    United States

    Active - Recruiting

  • Investigational center 485

    Atlanta, Georgia 30328
    United States

    Active - Recruiting

  • Investigational center

    Augusta, Georgia 30912
    United States

    Site Not Available

  • Investigational center 405

    Augusta, Georgia 30912
    United States

    Active - Recruiting

  • Investigational center

    Chicago, Illinois 60611
    United States

    Site Not Available

  • Investigational center 425

    Chicago, Illinois 60611
    United States

    Active - Recruiting

  • Investigational center 451

    Chicago, Illinois 60622
    United States

    Active - Recruiting

  • Investigational center

    Springfield, Illinois 77030
    United States

    Site Not Available

  • Investigational center 437

    Springfield, Illinois 77030
    United States

    Active - Recruiting

  • Investigational center

    Warrenville, Illinois 60555
    United States

    Site Not Available

  • Investigational center 458

    Warrenville, Illinois 60555
    United States

    Active - Recruiting

  • Investigational center

    Marrero, Louisiana 70072
    United States

    Site Not Available

  • Investigational center 465

    Marrero, Louisiana 70072
    United States

    Active - Recruiting

  • Investigational center

    Baltimore, Maryland 21204
    United States

    Site Not Available

  • Investigational center 472

    Baltimore, Maryland 21204
    United States

    Active - Recruiting

  • Investigational center

    Boston, Massachusetts 02131
    United States

    Site Not Available

  • Investigational center 455

    Boston, Massachusetts 02131
    United States

    Active - Recruiting

  • Investigational center

    Flowood, Mississippi 39232
    United States

    Site Not Available

  • Investigational center 417

    Flowood, Mississippi 39232
    United States

    Active - Recruiting

  • Investigational center

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Investigational center 482

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Investigational center

    St. Louis, Missouri 63141
    United States

    Site Not Available

  • Investigational center

    Omaha, Nebraska 68144
    United States

    Site Not Available

  • Investigational center 468

    Omaha, Nebraska 68144
    United States

    Active - Recruiting

  • Investigational center

    Las Vegas, Nevada 89124
    United States

    Site Not Available

  • Investigational center 438

    Las Vegas, Nevada 89124
    United States

    Active - Recruiting

  • Investigational center

    Marlton, New Jersey 08054
    United States

    Site Not Available

  • Investigational center 430

    Marlton, New Jersey 08054
    United States

    Active - Recruiting

  • Investigational center

    Cedarhurst, New York 11516
    United States

    Site Not Available

  • Investigational center 467

    Cedarhurst, New York 11516
    United States

    Active - Recruiting

  • Investigational center

    Glen Oaks, New York 11004
    United States

    Site Not Available

  • Investigational center 426

    Glen Oaks, New York 11004
    United States

    Active - Recruiting

  • Click Therapeutics

    New York, New York 10013
    United States

    Site Not Available

  • Investigational center

    New York, New York 10027
    United States

    Site Not Available

  • Investigational center 400

    New York, New York 10027
    United States

    Active - Recruiting

  • Investigational center 402

    New York, New York 10032
    United States

    Active - Recruiting

  • Investigational center 444

    New York, New York 10029
    United States

    Active - Recruiting

  • Investigational center

    Rochester, New York 14623
    United States

    Site Not Available

  • Investigational center 460

    Rochester, New York 14623
    United States

    Active - Recruiting

  • Investigational center

    Charlotte, North Carolina 27608
    United States

    Site Not Available

  • Investigational center 433

    Charlotte, North Carolina 27608
    United States

    Active - Recruiting

  • Investigational center 434

    Charlotte, North Carolina 28211
    United States

    Active - Recruiting

  • Investigational center 486

    Charlotte, North Carolina 28226
    United States

    Active - Recruiting

  • Investigational center

    Beachwood, Ohio 44122
    United States

    Site Not Available

  • Investigational center 412

    Beachwood, Ohio 44122
    United States

    Active - Recruiting

  • Investigational center

    Cincinatti, Ohio 45267
    United States

    Site Not Available

  • Investigational center

    Cincinnati, Ohio 45267
    United States

    Site Not Available

  • Investigational center 410

    Cincinnati, Ohio 45267
    United States

    Site Not Available

  • Investigational center

    Columbus, Ohio 43210
    United States

    Site Not Available

  • Investigational center 428

    Columbus, Ohio 43210
    United States

    Active - Recruiting

  • Investigational center

    Oklahoma City, Oklahoma 73116
    United States

    Site Not Available

  • Investigational center 440

    Oklahoma City, Oklahoma 73116
    United States

    Active - Recruiting

  • Investigational center

    State College, Pennsylvania 16801
    United States

    Site Not Available

  • Investigational center 484

    State College, Pennsylvania 16801
    United States

    Active - Recruiting

  • Investigational center

    Charleston, South Carolina 29425
    United States

    Site Not Available

  • Investigational center 443

    Charleston, South Carolina 29425
    United States

    Active - Recruiting

  • Investigational center

    Austin, Texas 78752
    United States

    Site Not Available

  • Investigational center 469

    Austin, Texas 78752
    United States

    Active - Recruiting

  • Investigational center

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Investigational center 416

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Investigational center

    Forth Worth, Texas 76104
    United States

    Site Not Available

  • Investigational center

    Houston, Texas 77030
    United States

    Site Not Available

  • Investigational center 436

    Houston, Texas 77030
    United States

    Active - Recruiting

  • Investigational center 447

    Houston, Texas 77081
    United States

    Active - Recruiting

  • Investigational center 448

    Houston, Texas 77055
    United States

    Active - Recruiting

  • Investigational center 473

    Houston, Texas 77088
    United States

    Active - Recruiting

  • Investigational center 478

    Houston, Texas 77077
    United States

    Active - Recruiting

  • Investigational center

    Irving, Texas 75062
    United States

    Site Not Available

  • Investigational center 403

    Irving, Texas 75062
    United States

    Active - Recruiting

  • Investigational center

    Mesquite, Texas 75149
    United States

    Site Not Available

  • Investigational center 453

    Mesquite, Texas 75149
    United States

    Active - Recruiting

  • Investigational center

    Plano, Texas 75093
    United States

    Site Not Available

  • Investigational center 452

    Plano, Texas 75093
    United States

    Active - Recruiting

  • Investigational center

    Saint George, Utah 84770
    United States

    Site Not Available

  • Investigational center 457

    Saint George, Utah 84770
    United States

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  • Investigational center

    Salt Lake City, Utah 84105
    United States

    Site Not Available

  • Investigational center 480

    Salt Lake City, Utah 84105
    United States

    Active - Recruiting

  • Investigational center

    St. George, Utah 84770
    United States

    Site Not Available

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