Cadonilimab in Combination With Chemotherapy for Locally Advaced Esophageal Squamous Cell Carcinoma

Inclusion Criteria:

• Age 18-70 years, both men and women
• Pathologically confirmed esophageal squamous cell carcinoma，and the clinic staging iscT2N1-3M0 or cT3N0-3M0 or cT4N0-3M0, TNM staging is II-IVA
• Non-cervical esophageal carcinoma
• Patients who have never received systemic antitumor therapy and who have measurablelesions that meet RECIST 1.1 criteria
• ECOG score 0-1
• Life expectancy ≥12 months
• Patients with normal function organs, no serious abnormalities of blood, heart, lung,liver, kidney function, and immunodeficiency disease
• For female subjects of childbearing age, they should have a negative urine or serumpregnancy test within 7 days before receiving the first study drug administration.Male and female patients need to use high-efficiency contraception during treatmentuntil at least 8 weeks after stop the treatment
• Sign the informed consent form before any trial-related procedures are implemented

Exclusion Criteria:

• -Other malignancies diagnosed within 5 years prior to the first administration of thestudy drug, except effectively treated basal cell carcinoma of the skin, squamous cellcarcinoma of the skin, and/or effectively resected in situ cervical and/or breastcancer
• ulcerative esophageal squamous cell carcinoma
• Esophageal or tracheal fistula
• History of allergy to study drug components
• History of immune disease
• Patients with any serious or uncontrolled systemic disease
• The presence of any adverse event (CTCAE>grade 1) caused by prior therapy