Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS

[PATIENTS] Inclusion Criteria:

• Has ALS, classified as definite, probable, laboratory-supported probable, or possibleALS according to the revised El Escorial criteria or a related neurodegenerativedisorder including ALS-FTD, PLS, PMA or asymptomatic individuals with a known ALSmutation (as previously confirmed during the individual's regular clinical care)
• Is the age of majority in their province of residence/treatment
• Has the cognitive capacity to provide informed consent
• Has proficiency in English or French in order to understand study instructions andrespond to questionnaires

Exclusion Criteria:

• Is pregnant
• Has a history of active (clinically significant) skin disorders
• Has a history of allergic response to plastic materials
• Has an electronic implant of any kind (e.g. pacemaker)
• Has broken, damaged or irritated skin or rashes near the sensor application sites
• Is unstably housed or lack reliable contact information.
• Investigator judges that device retrieval will be difficult or unlikely
• Does not have a smartphone that will support the HG application
• Does not have daily access to a wireless connection

[HEALTHY CONTROLS] Inclusion Criteria:

• Be between the ages of 40-80 unless age matched to a patient (+/-3 years) who isalready enrolled.
• Is the age of majority in their province of residence/treatment
• Has the cognitive capacity to provide informed consent
• Has proficiency in English or French in order to understand study instructions andrespond to questionnaires Exclusion Criteria:
• Has a history of a neurological disease, including Central Nervous System disease (e.g., stroke, head injury, epilepsy) or Peripheral Nervous System disease (neuropathy, myopathy).
• Has a history of psychiatric disease (e.g., depression, bipolar disease) that isclinically diagnosed and/or with the current use of psychiatric medications (e.g.,antidepressants) for an indication of a psychiatric disease.
• Is pregnant
• Has a history of active (clinically significant) skin disorders
• Has a history of allergic response to plastic materials
• Has an electronic implant of any kind (e.g. pacemaker)
• Has broken, damaged or irritated skin or rashes near the sensor application sites
• Is unstably housed or lack reliable contact information.
• Investigator judges that device retrieval will be difficult or unlikely
• Does not have a smartphone that will support the HG application
• Does not have daily access to a wireless connection