A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities

Inclusion Criteria:

• Have a body mass index (BMI) of ≥30 kilogram per square meter (kg/m²) or ≥27 kg/m²and previously diagnosed with at least one of the following weight relatedcomorbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovasculardisease

• Have a history of at least 1 unsuccessful dietary effort to lose body weight

Exclusion Criteria:

• Diabetes mellitus

• Change in body weight greater than 5 kg within 3 months prior to starting study

• Obesity induced by other endocrinologic disorders or monogenetic or syndromic formsof obesity

• History of pancreatitis

• Family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2)

• History of significant active or unstable major depressive disorder (MDD) or othersevere psychiatric disorder within the last 2 years