Application Circulating Tumor DNA Dynamic Monitoring in Clinical Treatment of Metastatic Renal Cell Carcinoma

Phase

N/A

Condition

Carcinoma

Treatment

N/A

Clinical Study ID

NCT05816642

MRCC-China collaboration

All Genders

Study Summary

Next-Generation Sequencing and whole transcriptome RNA sequencing were used to detect genomic variation and expression in tissues or blood, respectively. The treatment outcome of single targeted therapy or combined with immunotherapy was observed and followed up. Through this study, we intend to achieve RNA molecular classification of Chinese mRCC patients and to evaluate the correlation between ctDNA level, RNA molecular classification and treatment outcome, provide reference for metastatic RCC precise diagnosis and treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Clinically diagnosed with renal cell carcinoma confirmed by pathology, including clearrenal cell carcinoma and type I papillary renal cell carcinoma, type II papillaryrenal cell carcinoma, chromophobe renal cell carcinoma and renal cell carcinoma withsarcomatoid differentiation, etc
Have distant metastasis
metastatic RCC
Eastern Cooperative Oncology Group 0 to 1
No obvious abnormality was found in blood routine examination, coagulation andliver and kidney function

Exclusion

Exclusion Criteria:

• Previously received systematic treatment
Failure to obtain baseline tumor tissue / blood samples
A history of infection with human immunodeficiency virus, or suffer from otheracquired and congenital immunodeficiency diseases, or have a history of organtransplantation, or have a history of organ transplantation
A history of allergy to disease treatment drugs
During lactation or pregnancy

Study Design

August 01, 2022

December 31, 2024

Connect with a study center

Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai 200127
China
Active - Recruiting

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