Ebastine Versus Mebeverine in IBS Patients

Inclusion Criteria:

1. Voluntary written informed consent of the participant or their legally authorizedrepresentative has been obtained prior to any screening procedures

2. Patients fulfilling the Rome IV criteria for non-constipated IBS (IBS-C subtypeswill be excluded)

3. No organic cause that can explain the presenting symptoms (exclusion of coeliacdisease (blood), lactose intolerance (breath test), inflammatory bowel disease andgiardiasis (stool)

4. Patients with lactose intolerance can be included if no improvement on lactose freediet during 6 weeks

5. Age 18-65

Exclusion Criteria:

1. History of coeliac disease, food allergy, giardiasis, inflammatory bowel disease,infectious gastroenteritis, motility disorder, serious liver kidney cardiac orpulmonary disease, known cardiac rhythm disorders, insuline-dependent diabetes,psychiatric diseases

2. Pregnancy, breast feeding

3. Medication: the use of antidepressants or antipsychotics, anti-allergic medicationor drugs affecting gastrointestinal motility / visceral sensitivity (anti-cholinergics, antispasmodics, 5-HT3 antagonists, 5-HT4 agonists, loperamide,codeine, laxatives, analgesics: only paracetamol is allowed as analgetic, otheranalgesics are forbidden.), CYP3A4-inducing and inhibiting drugs. Potent inhibitorsof CYP3A4 include clarithromycin, erythromycin, diltiazem, itraconazole,ketoconazole, ritonavir, verapamil, goldenseal and grapefruit. Inducers of CYP3A4include phenobarbital, phenytoin, rifampicin, St. John's Wort and glucocorticoids.

4. Symptoms started following abdominal surgery

5. IBS constipation dominant (IBS-C)

6. Hypersensitivity to the active substance or to any of the excipients listed insection 6.1 of the SmPC of the respective medicinal products