A Phase 3 Study to Evaluate the Efficacy of XW003 in Adults With Overweight or Obesity

Inclusion Criteria:

1. Male or female, 18-75 years old, inclusive;

2. BMI between 24.0 to 28.0 kg/m2 with at least one comorbidity, including prediabetes,hypertension, hyperlipidemia, fatty liver , obstructive sleep apnea syndrome, etc.;or BMI ≥ 28 kg/m2 with or without comorbidities.

3. Weight change of no more than 5% (based on self-report), with diet and exercisealone, within 3 months before screening.

4. Willing and able to maintain stable diet and exercise during the study period.

Exclusion Criteria:

1. Obesity induced by endocrine diseases such as hypothyroidism, Cushing Syndrome, etc.

2. History of bariatric surgery (except liposuction >1 year ago) or planned bariatricsurgery during the study period.

3. Within 3 months before screening, history of using the following drugs ortreatments:

4. Any approved or unapproved weight-loss drugs or Chinese herbs or healthproducts that affect body weight.

5. Any hypoglycemic medication.

6. Any medication that may cause significant weight gain, including systemicglucocorticoid treatment, tricyclic anti-depressants, anti-epileptic andantipsychotics.

7. Any investigational drug, vaccine, or medical device.