Efficacy of Periorbital Rejuvenation With a 1927 nm Diode Laser Treatment

Last updated: June 2, 2025
Sponsor: National Taiwan University Hospital
Overall Status: Completed

Phase

N/A

Condition

N/A

Treatment

Periorbital rejuvenation with a 1927 nm diode laser treatment (4-week interval)

Periorbital rejuvenation with a 1927 nm diode laser treatment (2-week interval)

Clinical Study ID

NCT05811026
202207219DSC
  • Ages 30-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this research project is to investigate the treatment design, therapeutic effects and safety of the 1927 nm laser for the rejuvenation of the skin around the eyes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. aged between 30 and 65 years old;

  2. no significant skin lesions or inflammation on the facial skin;

  3. willing and able to comply with study requirements, instructions, and restrictions;

  4. signed informed consent form.

Exclusion

Exclusion Criteria:

  1. underwent facial active treatment, such as using laser, intense pulsed light,radiofrequency skin tightening, ultrasound skin tightening, botulinum toxin, ordermal fillers injection, within the previous six months;

  2. have chronic skin diseases such as atopic dermatitis, psoriasis, chronic urticaria,vitiligo, rosacea, or keloid;

  3. pregnant or breastfeeding;

  4. suffered from acute illnesses or infections requiring treatment within 14 daysbefore entering the study;

  5. have had serious illnesses (such as heart disease, lung disease, brain disease, orliver disease) within the previous three months;

  6. allergic to Lidocaine or Prilocaine used in topical anesthetic cream or suffer frommethemoglobinemia;

  7. used any skin medication on the face within 30 days before the trial, deemed by theprincipal investigator to affect the study results;

  8. deemed unsuitable for the study by the principal investigator.

Study Design

Total Participants: 20
Treatment Group(s): 2
Primary Treatment: Periorbital rejuvenation with a 1927 nm diode laser treatment (4-week interval)
Phase:
Study Start date:
March 15, 2023
Estimated Completion Date:
December 31, 2024

Study Description

The chromophore of the 1927 nm diode laser is mainly water, which can be used for skin rejuvenation. This study intends to use the Solta CLEAR+BRILLIANT Laser System, featuring a 1927 nm diode laser with 5 mJ energy, a treatment spot of 140 μm, a treatment depth of 170 μm, and a treatment coverage of approximately 5% per energy level after four rounds of treatment using the patented Intelligent Optical Tracking® System (IOTs). The purpose of this research project is to investigate the treatment design, therapeutic effects and safety of the 1927 nm laser for the rejuvenation of the skin around the eyes. This is an open-label, single-center clinical trial. Participants will be randomized into treatment groups, including Group A (treatment interval of 2 weeks) or Group B (treatment interval of 4 weeks).

Connect with a study center

  • National Taiwan University Hospital

    Taipei, 100229
    Taiwan

    Site Not Available

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