A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

Key Inclusion Criteria:

1. Eastern Cooperative Oncology Group (ECOG) performance status ≤1.

2. Metastatic prostate adenocarcinoma without small-cell carcinoma or neuroendocrinefeatures.

3. Prior therapy with a second-generation androgen receptor (AR)-targeted therapy (e.g., abiraterone, enzalutamide, apalutamide, darolutamide).

4. Prior therapy with a taxane regimen or are considered ineligible for treatment witha taxane regimen or have refused treatment with a taxane regimen, unless otherwisespecified.

5. For participants with a known pathogenic breast cancer gene 1 (BRCA1) or BRCA2mutation: prior therapy with a poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) inhibitor, or are considered ineligible for treatment with a PARP inhibitor,if such therapy is approved and available.

Key Exclusion Criteria:

1. Treatment with any approved systemic anti-cancer therapy within 14 days or 5 drugelimination half-lives (whichever is longer, not to exceed 28 days) prior to thefirst study treatment.

2. Treatment with any investigational agent within 28 days prior to the first studytreatment.

3. Treatment with any previous AR protein degrader.

4. Untreated central nervous system (CNS) metastases or leptomeningeal disease.

Note: Other protocol specified inclusion/exclusion criteria may apply.