Effectiveness of Testofen Compared to Placebo on Long COVID Symptoms

Last updated: March 6, 2025
Sponsor: RDC Clinical Pty Ltd
Overall Status: Completed

Phase

3

Condition

Covid-19

Treatment

Testofen

Microcrystalline cellulose

Clinical Study ID

NCT05795816
FENCOV
  • Ages > 18
  • All Genders

Study Summary

This is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed Testofen (a specialised extract of Trigonella foenum-graecum (Fenugreek) seed) compared to placebo on post COVID-19 symptoms in otherwise healthy participants 18 years and over.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults 18 years and over

  • Able to provide informed consent

  • Diagnosed with COVID-19 infection (RAT or PCR test) >4 weeks, but < 12 months andexperiencing post COVID symptoms (1)

  • Agree not to participate in another clinical trial while enrolled in this trial

  1. Common post COVID symptoms may include fatigue, cough, chest pain, hair loss,weakness, joint pain, cardiac issues, neurocognitive impairment includingmemory loss, and decreased quality of life

Exclusion

Exclusion Criteria:

  • Symptoms resulting from vaccination (2)

  • Unstable or serious illness (e.g., serious mood disorders, neurological disorderssuch as MS, kidney disease, liver disease, heart conditions, diabetes, thyroid glanddysfunction) (3)

  • Current malignancy (excluding BCC) or chemotherapy and radiotherapy treatment formalignancy within the previous 2 years

  • Receiving/prescribed coumandin (Warfarin), heparin, dalteaparin, enoxaparin or otheranticoagulation therapy

  • Receiving pharmaceutical treatment for anxiety, libido, low energy

  • Active smokers, nicotine use, alcohol, or drug (prescription or illegal substances)abuse

  • Chronic past and/or current alcohol use (>14 alcoholic drinks per week)

  • Allergic to any of the ingredients in the active or placebo formula

  • Known pregnant or lactating women

  • Any condition which in the opinion of the investigator makes the participantunsuitable for inclusion

  • Participants who have participated in any other related clinical study during thepast 1 month

  • History of infection in the month prior to the study

(2) Symptoms must be as a direct result of having contracted COVID. If symptoms onlyappeared within 2 weeks of a vaccination it will be considered a vaccine injury andnot classed as a result of COVID.

(3) An unstable illness is any illness that is currently not being treated with astable dose of medication or is fluctuating in severity. A serious illness is acondition that carries a risk of mortality, negatively impacts quality of life anddaily function and/or is burdensome in symptoms and/or treatments.

Study Design

Total Participants: 150
Treatment Group(s): 2
Primary Treatment: Testofen
Phase: 3
Study Start date:
October 25, 2023
Estimated Completion Date:
January 31, 2025

Connect with a study center

  • RDC Clinical Pty Ltd

    Brisbane, Queensland 4006
    Australia

    Site Not Available

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