A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors

Key Inclusion Criteria:

1. Age ≥18 years.

2. Unresectable or metastatic, relapsed/refractory, clear cell renal cell carcinoma,cervical carcinoma, pancreatic adenocarcinoma, esophageal carcinoma, and malignantpleural mesothelioma.

3. Eastern Cooperative Oncology Group performance status 0 or 1.

4. Adequate renal, liver, cardiac and pulmonary organ function.

5. Female subjects of childbearing potential and male subjects must agree to useacceptable method(s) of contraception from enrollment through at least 12 monthsafter CTX131 infusion.

Key Exclusion Criteria:

1. Prior treatment with anti-CD70 targeting agents

2. History of certain central nervous system (CNS), cardiac or pulmonary conditions.

3. Presence of uncontrolled bacterial, viral, or fungal infection.

4. Active HIV, hepatitis B virus or hepatitis C virus infection.

5. Primary immunodeficiency disorder or active autoimmune disease requiring steroidsand/or other immunosuppressive therapy.

6. Women who are pregnant or breastfeeding.