Lung Tumor Protein Synthesis Rates in Lung Cancer Patients

Last updated: March 31, 2023
Sponsor: Maastricht University Medical Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Disease

Non-small Cell Lung Cancer

Lung Cancer

Treatment

N/A

Clinical Study ID

NCT05794529
METCZ20220060
  • Ages 18-65
  • All Genders

Study Summary

The current study will recruit lung cancer patients to measure tissue protein synthesis rates of non-small cell lung carcinomas and healthy lung tissue. The protein synthesis rates of healthy lung tissue will be compared to lung tumor tissue to establish the remodeling characteristics of healthy versus cancerous lung tissues. We will also examine whether tissue protein synthesis rates of non-small cell lung carcinomas are associated with various tumor- (i.e., size, subclassification) and patient-derived (i.e., inflammation, lung function, smoking status, and smoking history) parameters.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Aged 18-65 years
  2. Compos mentis
  3. Diagnosed with lung cancer, with treatment requiring a thoracotomy or VATS lobectomy

Exclusion

Exclusion Criteria:

  1. Neoadjuvant chemo- or radiotherapy in the past four weeks
  2. Use of systemic steroids in the past four week
  3. Insulin-dependent diabetes mellitus
  4. Pregnancy

Study Design

Total Participants: 30
Study Start date:
March 01, 2023
Estimated Completion Date:
March 31, 2026

Connect with a study center

  • Zuyderland Medical Center

    Heerlen, Limburg 6419 PC
    Netherlands

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.