A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

Phase

N/A

Condition

Cardiovascular Disease

Occlusions

Congestive Heart Failure

Treatment

Coronary angiogram with coronary reactivity testing (CRT)

Clinical Study ID

NCT05793567

22-012721

Ages > 18
All Genders

Study Summary

The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).

Eligibility Criteria

Inclusion

Inclusion Criteria:

Ability to give informed consent
Structurally normal heart (normal LV and RV function, no more than mild valvularheart disease)
For controls: atypical chest pain with indication for CMD testing
For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise/fall of troponin with at least 1 value >99th centile+ evidence of symptoms orsigns of myocardial ischemia)

Exclusion

Exclusion Criteria:

Acute coronary event (evidence of plaque rupture, fissure or dissection on coronaryangiogram)
Known to have angiographically significant CAD/pressure wire positive for epicardialCAD
Inability to receive heparin products
Allergy/contraindication to acetylcholine/adenosine/nitroglycerine products
Prior coronary artery bypass grafting
Pregnancy (if sexually active woman of reproductive age, need negative pregnancytest prior to proceeding with coronary angiography - this is standard of care incath lab)
Asthma with prior ICU admission due to bronchospasm/need for invasive ventilation

Study Design