The Intervention of Obesity in Children With Prader-Willi Syndrome Using Prebiotics and Probiotics

Inclusion Criteria:

• Pre-adolescent children with Prader Willi syndrome which were definitely diagnosedby gene testing.

• Consistent with the diagnostic criteria for obesity.

• Not participate in other research projects at present or three months before theresearch;

• Agree to participate in the test and obtain the consent of their parents;voluntarily be the subjects and sign the informed consent form.

Exclusion Criteria:

• Losing weight in ways other than the intervention measures of this project, such astaking weight loss drugs or known drugs that cause weight change;

• Use antibiotics within 1 month before the study and lasted for 3 days or more;

• Use probiotics within 1 month before the study and lasted for 3 days or more;

• Complicated with liver and renal insufficiency (alanine aminotransferase and serumcreatinine indexes exceed 2 times the upper limit of the normal value set by thehospital);

• Have gastrointestinal diseases affecting food digestion and absorption (such assevere diarrhea, constipation, severe gastrointestinal inflammation, activegastrointestinal ulcer, acute cholecystitis, etc.); severe diarrhea refers to waterystool 3 or more times a day and lasts for 3 or more days. severe constipation refersto defecation 2 or less times a week with difficulty in defecation;

• Surgery was performed within 1 year before the study (except for appendicitis andhernia surgery);

• Have hepatitis B, active tuberculosis, AIDS and other infectious diseases;

• Those who are suffering from mental illness and are taking psychotropic drugs suchas antidepressants.