Comparison of Dequalinium Chloride (Fluomizin) vs Oral Metronidazole for the Treatment of Bacterial Vaginosis

Inclusion Criteria:

1. Premenopausal woman ≥18 years

2. Diagnosis of bacterial vaginosis (all 4 Amsel criteria positive, i.e. 1) greyishwhite thin discharge, 2) postassium hydroxide (KOH) test or 'fishy' smell, 3)microscopic presence of > 20% clue cells, 4) vaginal pH > 4.5)

3. Signed Written Informed Consent to participate in this study

Exclusion Criteria:

1. Pregnancy and/or lactation based on urine Pregnancy test (women with childbearingpotential should use any contraception excluding vaginal methods like vaginal ring,etc.)

2. Uterine bleeding (including menstruation) or vaginal bleeding of unknown origin

3. Ulcerations/erosions of vaginal mucosa or cervix uteri

4. Patients with clinical symptoms and findings of Candida vulvovaginitis and/orAerobic vaginitis

5. Clinically manifest or suspicion of sexually transmitted infections (Neisseriagonorrhoeae, Chlamydia trachomatis, or Trichomonas vaginalis) based on signs,symptoms, and anamnesis

6. Use of any antimicrobial treatment (local or systemic) 14 days before entry thestudy

7. Use of any vaginal medication or vaginal douching 7 days before entry the study

8. Unwillingness to refrain from alcohol consumption during treatment, and 48 hoursafter treatment

9. Severe systemic diseases (HIV, cancer, tuberculosis, autoimmune diseases, diabetesmellitus, severe psychiatric conditions, etc.), including diseases treated withimmunosuppressive therapies, systemic corticosteroids, or warfarin

10. Known or suspected hypersensitivity to one of the study medications, inclusive oftheir excipients

11. Inability to follow the procedures of the study, e.g. due to language problems,psychological disorders, dementia, etc. of the participant (including inability tofill-in electronic patient diary)

12. Participation of patient in another investigational drug study concomitantly orwithin 30 days prior to entry in the study

13. Patient is relative of, or staff directly reporting to, the investigator