Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

Phase

N/A

Condition

Addictions

Alcohol Use Disorder

Alcohol Dependence

Treatment

Alcohol Administration

Clinical Study ID

NCT05786157

Pro00127577

Ages > 21
All Genders

Study Summary

Intimate partner violence (IPV) is a serious public health problem that results in significant health and economic burdens including mortality, morbidity, and poor treatment outcomes. A well-developed field of research suggests that alcohol misuse and posttraumatic stress disorder (PTSD) can lead to IPV. Individuals with PTSD and/or problematic drinking behaviors are at risk for IPV because of several factors that are common symptoms of PTSD. Because individuals with PTSD often drink alcohol to "self-medicate" or cope with distressing PTSD symptoms, PTSD co-occurs with alcohol misuse and alcohol use disorder at extraordinarily high rates. However, few studies have examined the combined effects of alcohol misuse and PTSD on any form of violence.

This study will examine the effects of alcohol misuse and posttraumatic stress disorder (PTSD) on alcohol-related intimate partner violence (IPV). We will examine these associations among couples (N=70) in a controlled laboratory setting using validated, standardized methods in a 'real-world' settings using 28 days of ecological momentary assessment (EMA).

Eligibility Criteria

Inclusion

Inclusion criteria

Any gender identity; any race or ethnicity; ages 21 years or older.
Must report ≥ 2 heavy drinking episodes in the past 30 days (i.e., 4 or more drinksfor women, 5 or more for men in ≤ 2 hours) and consumed a quantity of alcohol thatis equal to or greater than the standard dose administered for their weight in thelaboratory (assessed via the TLFB).
At least one instance of physical IPV in the current relationship reported by atleast one partner within the couple (assessed by the CTS-2).
Participants must agree not to drive or operate machinery for the remainder of theexperimental visit day. Transportation will be provided if necessary.
One or both partners in half the couples will be required to meet diagnosticcriteria for PTSD or subthreshold PTSD (assessed by the CAPS-5).

Exclusion

Exclusion criteria:

Possible drug use disorder (except caffeine or nicotine) as meeting DSM-5 diagnosticcriteria via the QuickSCID; Recent recreational drug use (e.g., cannabis) isacceptable.
Severe alcohol use disorder as meeting DSM-5 diagnostic criteria via the QuickSCID.Applies to those receiving alcohol administration only.
Meeting DSM-5 criteria for a history of or current psychotic or bipolar disorders.
Current suicidal or homicidal ideation and intent.
History of or current psychiatric or medical condition for which alcoholadministration is medically contraindicated.
Body weight > 250 lbs (in order to rigorously control alcohol dosing). Applies tothose receiving alcohol administration only.
Use of medications such as lithium, methadone, alpha or beta blockers orcholinergic/ anticholinergic drugs likely to confound normative cardiovascularresponding for the psychophysiological component of the project. Applies to thosereceiving alcohol administration only.
Pregnancy or breastfeeding.
Severe or unilateral partner violence in the past 6 months as measured by the CTS-2.

Study Design

Alcohol Administration

March 01, 2024

October 01, 2029

Study Description

Alcohol misuse has a salient precipitous effect on intimate partner violence (IPV), which is a persistent public health crisis affecting approximately one-third of the U.S. population. Posttraumatic stress disorder (PTSD) is highly prevalent, has a clear causal effect on alcohol misuse, and it is a robust independent predictor of IPV. However, few studies have examined the combined effects of PTSD and alcohol misuse on IPV. This question is critical to address because effective prevention and treatment approaches for alcohol-related IPV are scant. Integrating these two siloed areas of the literature can help inform the development of novel, trauma-informed modalities for couples to produce stronger and more sustainable outcomes. Dr. Flanagan is the ideal candidate to advance the clinical science in this area. Under the proposed mid-career development award, she will accelerate her thriving patient-oriented alcohol research program by enhancing her skills with 1) oral alcohol administration, 2) intensive ambulatory assessment, and 3) psychophysiology. She will achieve these goals through expert consultation, didactic training, and implementation of the proposed research project. Her team will examine the combined effects of alcohol misuse and PTSD on alcohol-related IPV among couples (N=70) in both a controlled laboratory setting and in naturalistic settings. The study, which was designed to complement mentees' independent research interests, will also compare outcomes across settings and explore heart rate variability as a physiological mechanism underlying the hypothesized relations. The invaluable protected time and resources provided by this K24 will enable Dr. Flanagan to achieve her primary goal of expanding her mentoring availability and skillset at this pivotal mid-career stage. She will engage a program of didactics and expert coaching to amplify her investment in diversity, equity, and inclusion in mentoring, leadership, and science. Achieving these synergistic objectives will accelerate the science of couple and family alcohol research and set the stage for innovative new dyadic treatments. This award will also ensure that Dr. Flanagan is equipped to support the next generation of enthusiastic new investigators and to ensure the longevity of this vital yet underrepresented area of the alcohol field.

Connect with a study center

Medical University of South Carolina
Charleston, South Carolina 29425
United States
Active - Recruiting
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040 29425
United States
Site Not Available

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