A Study of Oral Minoxidil to Treat Hair Loss in Children, Teens, and Young Adults Who Are Cancer Survivors

Inclusion Criteria:

• Patients must have been diagnosed with cancer before the age of 17.

• They must have completed either systemic or radiation therapy (cytotoxicchemotherapy and external beam radiation therapy) for their cancer at least 1 yearprior to study entry.

• They must be between 6-18 years old at the time of enrollment.

• They must have a clinical diagnosis of persistent or late alopecia for >6 months andthat is definitely, probably, or possibly related to prior chemotherapy and/orradiation.

Exclusion Criteria:

• Had a history of alopecia prior to systemic or radiation therapy for cancer, or hasalopecia unrelated to cancer treatment.

• Have scalp disorders that preclude the evaluation of alopecia, such as psoriasis

• Has a known hypersensitivity to minoxidil

• Concurrent use of other therapies for alopecia

• Concurrent active anticancer therapies (cytotoxic, targeted, endocrine, immunologic)

• History of chronic sclerotic cutaneous GvHD affecting the scalp

• Active chronic cutaneous GvHD

• History of orthostatic or symptomatic hypotension, syncope related to hypotension;systolic less than or equal than 100 (for adults) and 90 (for children) atscreening.

• Pregnancy.

• Cardiovascular disease that in the opinion of the cardiologist makes the patientunsuitable for therapy

• Blood pressure less than the 5th percentile or less than 90/50 mmHg for children 10years or older