The Effect of Intraoperative Ventilation Mode on Hemodynamics and Lung Dynamics

Last updated: March 8, 2023
Sponsor: Izmir Ataturk Training and Research Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT05776589
Izmir ATRH
  • Ages 18-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

In this study, it was aimed to compare the effects of pressure-controlled volume-guaranteed ventilation (PCV-VG) and volume-controlled ventilation (VCV) on lung dynamics and hemodynamics in patients undergoing vertebral surgery in the prone position.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who will undergo thoracolumbar vertebral surgery in the prone position
  • Patients older than 18 years
  • Patients younger than 70 years of age
  • ASA 1-2 patients

Exclusion

Exclusion Criteria:

  • Patients with a BMI >30 kg/m2
  • Patients with a history of chronic pulmonary disease
  • Patients with a history of previous thoracic surgery
  • Patients with ASA >3
  • Patients who will undergo emergency surgery
  • Pregnant patients

Study Design

Total Participants: 72
Study Start date:
February 01, 2023
Estimated Completion Date:
April 30, 2023

Study Description

The VCV (volume controlled ventilation) mode is the mode commonly used in general anesthesia practice. In VCV mode, the parameters under control are tidal volume and respiratory rate. In VCV mode, airway pressure changes depending on resistance and compliance. There is a risk of increased airway pressures in this mode.

In PCV-VG (pressure controlled volume guaranteed ventilation) mode, the parameters under control are the peak airway inspiratory pressure and the I/E ratio. It has been shown that peak airway pressures decrease and partial oxygen pressure increase due to decreased inspiratory flow in this ventilation mode.

Both ventilation modes are frequently used in patients undergoing general anesthesia.

In this study, it was aimed to compare the effects of pressure-controlled volume-guaranteed ventilation (PCV-VG) and volume-controlled ventilation (VCV) on lung dynamics (pulmonary peak-plateau pressure, compliance, driving pressure, SpO2 and end-tidal carbon dioxide) and hemodynamics (mean arterial pressure and heart rate) in patients undergoing vertebral surgery in the prone position.

In the study, patients will be randomized and divided into 2 groups after obtaining informed consent forms. If a mode change is required during the surgery, that patient will be excluded from the study.

Connect with a study center

  • KCU Izmir Atatürk Training and Research Hospital

    Izmir, 35150
    Turkey

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.