Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints

Phase

Condition

Post-traumatic Stress Disorders

Treatment

Placebo

Methylphenidate

Clinical Study ID

NCT05776056

MHBP-006-22S

CX002546

Ages 18-65
All Genders

Study Summary

Posttraumatic stress disorder (PTSD) is frequently accompanied by difficulty concentrating, poor memory, and inability to keep up with tasks, which negatively impacts a person's ability to function at work and in relationships. Currently available treatments do not fully relieve all symptoms. A published research report showed positive evidence that the stimulant medication methylphenidate was beneficial in treating these problems. This study will evaluate the ability of methylphenidate to treat PTSD and associated neurocognitive complaints in Veterans. An innovative feature is the study's N-of-1 design. In this design, every participant will move back and forth every 4-5 weeks between treatment with methylphenidate and treatment with placebo, in random order and under double-blind conditions, over a 20-week period. The investigators will compare the aggregated change in PTSD and neurocognitive symptoms between periods of treatment with methylphenidate versus placebo. Results will help clinicians to better choose the best treatment for Veterans living with PTSD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Any gender Veteran of the US military between the ages of 18 and 65 years
Independent decision-making capacity to sign informed consent and HIPAA (i.e., nosurrogate consent)
Diagnosis of PTSD defined by DSM-5 symptom count on CAPS-5
CAPS-5 past month total score greater than or equal to 26
Subjective neurocognitive impairment, defined as a total score of greater than orequal to 25 (1 standard deviation below the mean) on the NeuroQoL Cognitive Function 8-item self-report form.

Exclusion

Exclusion Criteria:

Diagnosis of DSM-5-defined bipolar I, schizophrenia spectrum or other psychoticdisorders (by MINI)
Presence of severe psychotic symptoms such that, based on the clinical judgement ofthe investigator or treatment provider, treatment with an antipsychotic is required.
Diagnosis of moderate or severe substance use disorder (except for caffeine andnicotine) during the preceding 2 months. Patients who utilize alcohol or cannabisbut do not meet criteria for moderate or severe disorder are permitted at thediscretion of the investigator. Participants must agree to abstain from illicitdrugs, including cannabis products containing THC even when legal by state law.
History of severe TBI as defined by the Ohio State University TBI IdentificationMethod.
Diagnosis of dementia or related progressive neurocognitive disorder, based onclinical records.
Increased risk of suicide that necessitates inpatient treatment or treatmentexcluded by the protocol; and/or intensity of suicidal ideation (Type 4 or Type 5)or any suicidal behavior in the past 2 months on Columbia Suicide Severity RatingScale (C-SSRS).
Pregnancy or lactation, or anticipated pregnancy at any point during studyparticipation. Participants of child-bearing potential must have negative pregnancytest at study entry and must agree to adhere to a medically acceptable method ofbirth control (e.g., oral, implantable, injectable, or transdermal hormone-basedcontraceptives; intrauterine device; double-barrier method).
Use of any investigational drug, MPH formulation, antipsychotics, mood stabilizers,monoamine oxidase inhibitors, stimulants, atomoxetine, or bupropion within 2 weeksof baseline.
Treatment with evidence-based trauma-focused therapy for PTSD within 2 weeks ofbaseline (if participant is receiving therapy, he/she must complete treatment priorto entering study). Supportive psychotherapy may be continued during the study.
A clinically significant acute or uncontrolled chronic medical/surgical illness thatwould contraindicate use of MPH, or a known terminal illness.
Prior allergic reaction to any MPH formulation.
Litigating for compensation for a psychiatric disorder outside the Veterans benefitscompensation and pension process.
Current enrollment in another interventional trial for PTSD.

Study Design

Placebo

February 05, 2024

March 31, 2027

Study Description

Background: Posttraumatic stress disorder (PTSD) is a chronic psychiatric illness that is associated with significant suffering and disability in Veterans. Current treatment options are not fully effective for all Veterans, and even when they are effective in lowering total symptom burden, many Veterans continue to experience significant symptom burden and associated functional impairment. Total symptom burden and associated functional impairment is often particularly high for those with comorbid mild traumatic brain injury (mTBI). Methylphenidate (MPH) is a widely available psychostimulant medication with a long track record of safety, which has been used to improve cognitive functioning in attention deficit hyperactivity disorder (ADHD) and has also shown benefit for mood and cognitive functioning in studies of moderate or severe TBI and as augmentation in treatment-resistant major depressive disorder. In a small pilot study of the efficacy of MPH for subjective cognitive impairment associated with PTSD and/or mTBI, members of the research team found that MPH resulted in not only a significant improvement in subjective and objective measures of cognitive functioning, but also a significant decrease in symptoms of both depression and PTSD.

Methods: Here, the investigators propose to follow up this promising initial finding with an aggregated N-of-1 randomized placebo-controlled trial of MPH versus placebo (PBO) for PTSD and cognitive symptoms in Veterans with PTSD, with or without comorbid TBI. N=70 Veterans across two sites will each receive sequential 4-week periods of MPH and PBO, in randomized order and separated by a 1-week washout, for a total of 20 weeks. During this time, they will complete weekly or biweekly assessments. This trial design, which is particularly well-optimized for conditions in which a heterogeneous response to treatment is expected, will let us achieve a number of specific aims. First, the investigators will assess the efficacy of MPH compared to PBO for reducing PTSD and depression symptoms in Veterans with PTSD and neurocognitive complaints. Second, the investigators will assess the impact of MPH compared to PBO on neurocognitive functioning in this same population. And third, the investigators characterize the baseline predictors of treatment response to MPH in this population, including whether Veterans with a history of mTBI show greater average treatment response to MPH versus PBO. Finally, this trial design will also allow a systematic assessment of risks in this population, including the risk of discontinuation effects or loss of efficacy over time.

Significance: MPH represents a well-tolerated medication with a novel mechanism of action compared to the currently recommended and often ineffective pharmacologic treatments for PTSD and mTBI with associated cognitive complaints. If the results of this study support the use of MPH to decrease PTSD and neurocognitive symptoms in Veterans, it would provide an important new treatment option for Veterans with PTSD, which could be rapidly integrated into clinical practice.

Connect with a study center

Birmingham VA Medical Center, Birmingham, AL
Birmingham, Alabama 35233-1927
United States
Active - Recruiting
Tuscaloosa VA Medical Center, Tuscaloosa, AL
Tuscaloosa, Alabama 35404-5015
United States
Active - Recruiting
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington 98108-1532
United States
Active - Recruiting

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