Markers of Inflammation and of the Pro-thrombotic State in Hospital Shift and Day Workers

Last updated: August 30, 2024
Sponsor: Centro Cardiologico Monzino
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Inflammation

Insomnia

Narcolepsy

Treatment

Tests for markers of inflammation and activated hemostasis

Clinical Study ID

NCT05775731
CCM 1788
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this observational study is to learn if acutely and/or chronically altered sleep induces inflammation and/or a pro-thrombotic state (a tendency to form clots) in hospital workers who either work in shifts or are exclusively daily workers. The main questions it aims to answer are:

  • Does chronically altered sleep induce a pro-inflammatory and pro-thrombotic state, which are steps towards cardiovascular disease, knowing that is associated with poor sleep?

  • Does acutely disrupted sleep, such as that observed in night shift workers, induce a pro-inflammatory and pro-thrombotic state in otherwise healthy subjects? Participants in the study are hospital workers who either work in shifts, including night shifts, or only during the day. Sleep quality is assessed by a validated questionnaire (the Pittsburgh Sleep Quality Index). Markers of inflammation and of the pro-thrombotic state are measured at baseline and, if appropriate, after the night shift. These are markers of platelet activation, D-dimer, Interleukin-6 and endothelin 1, known to contribute and/or to suggest a condition of generalized inflammation and a tendency to form clots. Relevant information on health status is also collected for each participant.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Hospital worker who either works in shifts including night shifts, or only duringthe day

Exclusion

Exclusion Criteria:

  • Known sleep disorder diagnosed by polysomnography and/or nocturnal saturation study

  • Sleep apnea-hypopnea syndrome in C-PAP (Continuous Positive Airway Pressure)treatment

  • Chronic treatment with sleep-inducers

  • Chronic heart failure class NYHA III and IV

  • Ischemic heart disease

  • Venous thromboembolism

  • Chronic anticoagulant and/or anti-platelet therapy

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: Tests for markers of inflammation and activated hemostasis
Phase:
Study Start date:
September 27, 2022
Estimated Completion Date:
December 30, 2024

Study Description

Impaired sleep (quantity and quality) is associated with a number of chronic diseases, including an increased risk of cardiovascular events. Some forms of sleep impairment such as insomnia are very frequent and can be easily identified through dedicated and validated questionnaires. The pathway through which impaired sleep heightens cardiovascular risk is not known. Some limited studies suggest activation of coagulation could follow chronic sleep impairment. Atherosclerotic plaque formation is associated with the activation of coagulation, and with chronic inflammation. It would be interesting to know if chronic or acute sleep impairment, such as that experienced by night-shift hospital workers, could induce an inflammatory and pro-thrombotic state either acutely or chronically.

To test whether these hypotheses are correct, volunteer hospital workers who either work in shifts or do not will be enrolled, to test activation of inflammation and hemostasis through established markers (platelet, inflammation and coagulation activation markers). Shift workers will be analyzed before and after a night shift.

Data on anxiety and general health (chronic disorders, medications) as well as on sleep, through validated questionnaires, will be also collected.

Two groups: night-shift workers and daily workers will be compared. Comparisons will be carried out also within night-shift workers, at baseline and after a nigh shift. Finally, subjects who sleep well and who do not sleep well will be compared, independently of shift work.

The investigators believe that if it is shown that insomnia, a frequent and often not addressed sleep disturbance, is associated with a pro-inflammatory and pro-thrombotic state in otherwise healthy workers, this finding would have important consequences, first of all in designing prospective studies on the development of cardiovascular disease in altered sleep and its prevention.

Connect with a study center

  • Centro Cardiologico Monzino

    Milan, 20138
    Italy

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.