Phase
Condition
Nephropathy
Kidney Failure (Pediatric)
Kidney Disease
Treatment
Huaiqihuang Granule placebo
Huaiqihuang granule
Prednisone
Clinical Study ID
Ages 18-18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age from 1.5 to 18 years;
According to the Evidence-based Guideline for Diagnosis and Treatment ofHormone-sensitive, Relapsed/dependent Nephrotic Syndrome in Children (2016),children diagnosed with PNS;
At enrollment, estimated glomerular filtration rate (eGFR)≥90ml/min/1.73m2;
At enrollment, serum albumin level below 30g/L, and morning urine protein is 4+ orurinary albumin/creatinine ratio (ACR)≥2.0g/g;
Volunteered to participate in this study and signed informed consent. For childrenless than 8 years, legal guardians need to sign the informed consent.
Exclusion
Exclusion Criteria:
Children who were diagnosed as steroid-resistant NS;
Patients who received Prednisone, other corticosteroids (like Prednisolone,Methylprednisolone), or immunosuppressants (Tacrolimus, Mycophenolate Mofetil,Cyclosporine A, Rituximab, Cyclophosphamide) within 3 months before enrollment;
Secondary NS caused by lupus nephritis, hepatitis B associated nephritis, purpuranephritis, and EB virus, cytomegalovirus (CMV), etc;
With combined diseases of autoimmune disorder or primary immunodeficiency ormalignancy;
With combined diseases of the cardiovascular, liver, hematopoietic system, mentaldisorders, and other serious diseases;
With serious infectious diseases (like tuberculosis) in the past or at present;
With combined diseases of Human immunodeficiency virus (HIV), hepatitis B and /or Cvirus (HBV, HCV), and other active virus infections;
History of diabetes;
Abnormal liver function: alanine aminotransferase and aspartate aminotransferaselevels exceed twice the upper limit of the normal range;
Participation in other ongoing clinical trials;
Other reasons that the researcher considers unsuitable to participate in this study.
Study Design
Study Description
Connect with a study center
Anhui Children's Hospital
Hefei, Anhui
ChinaActive - Recruiting
Children's Hospital of Chongqing Medical University
Chongqing, Chongqing
ChinaActive - Recruiting
Fujian Children's Hospital
Fuzhou, Fujian
ChinaActive - Recruiting
People's Liberation Army Joint Logistics Force No. 900 Hospital
Fuzhou, Fujian
ChinaActive - Recruiting
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong
ChinaActive - Recruiting
Hebei Children's Hospital
Shijiazhuang, Hebei
ChinaActive - Recruiting
Harbin Children's Hospital
Harbin, Heilongjiang
ChinaActive - Recruiting
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, Henan
ChinaActive - Recruiting
Henan Children's Hospital
Zhengzhou, Henan
ChinaActive - Recruiting
The First Affliated Hospital of Zhengzhou University
Zhengzhou, Henan
ChinaActive - Recruiting
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei
ChinaActive - Recruiting
Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei
ChinaActive - Recruiting
Hunan Children's Hospital
Changsha, Hunan
ChinaActive - Recruiting
Children's Hospital of Soochow University
Suzhou, Jiangsu
ChinaActive - Recruiting
Baiqiu'en First Hospital of Jilin University
Changchun, Jilin
ChinaActive - Recruiting
Dalian Women and Children's Medical Centre
Dalian, Liaoning
ChinaActive - Recruiting
Shengjing Hospital of China Medical University
Shenyang, Liaoning
ChinaActive - Recruiting
Shandong Provincial Hospital
Jinan, Shandong
ChinaActive - Recruiting
Shanghai Children's Hospital
Shanghai, Shanghai
ChinaActive - Recruiting
Shanxi Children's Hospital
Taiyuan, Shanxi
ChinaActive - Recruiting
West China Second Hospital of Sichuan University
Chengde, Sichuan
ChinaActive - Recruiting
Chengdu Women's and Children's Central Hospital
Chengdu, Sichuan
ChinaActive - Recruiting
Tianjin Children's Hospital
Tianjin, Tianjin
ChinaActive - Recruiting
Xinjiang Uiger Municipal People's Hospital
Ürümqi, Xinjiang
ChinaActive - Recruiting
Children's Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang
ChinaActive - Recruiting
Ningbo Women's and Children's Hospital
Ningbo, Zhejiang
ChinaActive - Recruiting
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