Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas

Inclusion Criteria:

1. ≥18 years of age

2. Histologically confirmed HGG (WHO grade III or IV, including GBM, astrocytoma,gliosarcoma, H3K27M mutant diffuse midline glioma). Patients with methylated orunmethylated O(6)-methylguanine-DNA methyltransferase (MGMT) promoter are eligible,as are IDH WT and mutant patients as long as the treatment plan is for combinedXRT/TMZ. The neuropathologic diagnosis of HGG will be made at the respectiveinstitution. If any question arises regarding the accuracy of the neuropathologicdiagnosis, slides (and pathological blocks, if necessary) will be centrally reviewed

3. Planning standard therapy with TMZ and XRT for 6 weeks and adjuvant TMZ for six 28-day cycles.

4. Karnofsky Performance Scale (KPS) ≥ 70% Adequate organ and marrow function defined as:

• Hgb > 9 g/dL

• ANC ≥ 1500/µL

• Platelet count ≥ 100,000/µL

• Total bilirubin ≤ 1.5 * institutional ULN

• AST and ALT ≤ 3 * institutional ULN OR

• Estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 unless dataexist supporting safe use at lower values of renal function, but eGFR must be ≥ 30 mL/min/1.73 m2

5. Patients with human immunodeficiency virus (HIV) who are on effective antiretroviraltherapy are eligible if the viral load was assessed as undetectable within 6 monthsprior to baseline

6. Women: WOCBP must agree to use adequate contraception (hormonal or barrier method ofbirth control or abstinence) prior to study entry and for the duration of studyparticipation

7. Men: must agree to use adequate contraception prior to study entry, for the durationof study participation, and for 4 months after completion of LC administration

Exclusion Criteria:

1. Any concurrent cancer diagnosis that is untreated, actively treated, or hasundergone any therapy (XRT, cytotoxic, targeted, immunotherapeutic, etc.) within 2years of study enrollment, with the exception of squamous or basal cell skin cancer

2. Patient has not recovered from AEs due to prior anticancer therapy (i.e., residualtoxicities > Grade 1), with the exception of alopecia

3. Receiving any other investigational agent

4. Active infection requiring systemic antibiotics

5. History of allergic reaction to compounds that are chemically or biologicallysimilar to LC

6. Patient is taking a medication that may potentiate hemolysis

7. Unstable angina or myocardial infarction within the past 6 months

8. Prolonged QTc interval, Fridericia formula (QTcF) (> 450 msec for males or > 460msec for females)

9. Psychiatric illness or social situation that could limit compliance with studyrequirements

10. Pregnant or breastfeeding