Phase
Condition
Low Blood Sodium (Hyponatremia)
Low Blood Pressure (Hypotension)
Treatment
Nuun
Buoy Electrolyte
Water
Clinical Study ID
Ages 18-45 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Male or female, >18 to 45 years of age
Freely given written consent
Non-tobacco users
Negative pregnancy test in women of childbearing potential
BMI < 35 kg/m2
GFR > 60 ml/min
No known underlying medical condition
Willing to refrain from EtOH for 24h prior to test day
Willing to refrain from strenuous exercise for 24 h prior to each test day
Acceptable to have one 8oz cup of coffee/liquid on the morning of the test, but mustbe consistent each visit
Without active infection of any kind
Engaged in exercise three or more hours per week
Exclusion
Exclusion Criteria:
Abnormal creatinine (Cr > 1.2).
Proteinuria / hematuria / glucosuria based on urine dipstick.
Diagnosed medical condition that would impede results (CHF, HTN, CAD, CKD, historyof electrolyte abnormality).
Pregnancy
Use of diuretics within past 2 weeks
Obesity (BMI > 35)
Active infection based on symptoms (bacterial or viral)
Hemodynamic abnormality at screening visit: Blood pressure less than 100/60 orgreater than 140/90.
Study Design
Study Description
Connect with a study center
UPMC Montefiore Hospital
Pittsburgh, Pennsylvania 152132
United StatesSite Not Available
UPMC Presbyterian
Pittsburgh, Pennsylvania 15213
United StatesSite Not Available
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