A Study of Tumor-Treating Fields (TTFields) in People With Lung Adenocarcinoma

Last updated: May 27, 2026
Sponsor: Memorial Sloan Kettering Cancer Center
Overall Status: Active - Not Recruiting

Phase

1

Condition

Lung Cancer

Non-small Cell Lung Cancer

Adenocarcinoma

Treatment

NovoTTF-200T System

Clinical Study ID

NCT05764954
22-387
  • Ages > 22
  • All Genders

Study Summary

The researchers are doing this study to find out if treatment with TTFields using the NovoTTF-200T System is safe and practical (feasible) before surgical removal (resection) of lung adenocarcinoma (ADC). The researchers will also look at how the treatment may help the body's immune system to fight cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • The participant (or legally acceptable representative [LAR], if applicable) provideswritten informed consent for the study.

  • The participant is ≥22 years of age on the day of signing informed consent.

  • The participant has clinical stage 1A2, 1A3 or IB biopsy-proven lung ADC and iseligible for anatomical resection.

  • The participant has a lung nodule >1 cm and suspected lung ADC with a plan toundergo biopsy.

  • The participant with multiple nodules has one nodule that meets the criteria.

  • The participant has no history of prior malignancy in the chest or has undergonepotentially curative therapy with no evidence of that disease recurrence for 5 yearssince initiation of that therapy.

Exclusion

Exclusion Criteria:

  • Patients receiving therapy for concurrent active malignancy

  • Patients with a history of cardiac arrhythmias and/or pacemaker use

  • Patients with lung nodules <1cm

  • Patients with lung nodules that are pure ground glass opacities (GGOs) of any size

  • Patients with lung nodules that are <50% solid of any size

Study Design

Total Participants: 12
Treatment Group(s): 1
Primary Treatment: NovoTTF-200T System
Phase: 1
Study Start date:
August 04, 2023
Estimated Completion Date:
August 31, 2027

Connect with a study center

  • Memorial Sloan Kettering Basking Ridge (Consent Only)

    Basking Ridge, New Jersey 07920
    United States

    Site Not Available

  • Memorial Sloan Kettering Monmouth (Consent Only)

    Middletown, New Jersey 07748
    United States

    Site Not Available

  • Memorial Sloan Kettering Bergen (Consent Only)

    Montvale, New Jersey 07645
    United States

    Site Not Available

  • Memorial Sloan Kettering Suffolk - Commack (Consent Only)

    Commack, New York 11725
    United States

    Site Not Available

  • Memorial Sloan Kettering Westchester (Consent Only)

    Harrison, New York 10604
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    New York, New York 10065
    United States

    Site Not Available

  • Memorial Sloan Kettering Nassau (Consent Only)

    Uniondale, New York 11553
    United States

    Site Not Available

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