DAOIB for the Treatment of Brain Fog

Last updated: June 16, 2024
Sponsor: Chang Gung Memorial Hospital
Overall Status: Active - Recruiting

Phase

2

Condition

N/A

Treatment

DAOIB

Clinical Study ID

NCT05764538
202200988A3
  • Ages 18-100
  • All Genders

Study Summary

This is a 24-week open trial. We will enroll long-COVID patients with cognitive impairments. All patients will receive DAOIB for 24 weeks. We will assess the patients every 8 weeks during the treatment period (weeks 0, 8, 16, and 24). We hypothesize that DAOIB treatment will be beneficial in improving the cognitive function, mood symptoms, global functioning and quality of life in long-COVID patients with cognitive impairments.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • "post-COVID-19 condition" defined by WHO (symptoms present at three months afterSARS-CoV-2 infection and last for at least 2 months which cannot be explained by analternative diagnosis)(Cabrera Martimbianco, Pacheco et al. 2021) and COVID-inducedcognitive impairments

  • physically healthy and have all laboratory assessments (including urine/bloodroutine, biochemical tests, and electrocardiograph) within normal limits

  • have sufficient education to communicate effectively and are capable of completingthe assessments of the study

Exclusion

Exclusion Criteria:

  • history of significant cerebrovascular disease

  • Hachinski Ischemic Score > 4

  • major neurological, psychiatric or medical conditions other than long COVID-inducedcognitive impairments

  • memantine use (memantine is an NMDAR partial antagonist)

  • substance (including alcohol) abuse or dependence

  • delusion, hallucination or delirium symptoms

  • severe visual or hearing loss

  • inability to follow the protocol

Study Design

Total Participants: 40
Treatment Group(s): 1
Primary Treatment: DAOIB
Phase: 2
Study Start date:
February 27, 2023
Estimated Completion Date:
February 28, 2025

Connect with a study center

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung, 886
    Taiwan

    Active - Recruiting

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