Duration of Antibiotic Treatment in Community-acquired Pneumonia

Last updated: January 9, 2024
Sponsor: Instituto de Investigacion Sanitaria La Fe
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pneumonia

Pneumonia (Pediatric)

Treatment

Reminders to the assistant clinicians of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment community-acquired pneumonia

Clinical Study ID

NCT05762328
2022-914-1
  • Ages 18-100
  • All Genders

Study Summary

International and national clinical guidelines recommend short antibiotic regimens in patients with non-severe community-acquired pneumonia (CAP) who have reached clinical stability. However, adherence to these recommendations remains unclear. The goals of this quasi-experimental trial are: 1) to assess adherence to clinical guidelines in relation to the duration of antibiotic treatment in patients hospitalized for non-severe CAP who have reached clinical stability; 2) increase adherence to clinical guidelines and reduce the use of antibiotics in patients hospitalized for non-severe CAP who have achieved clinical stability after at least 5 days of antibiotic treatment.

To this end, a multicenter prospective study will be carried out over 2 years and divided into 2 phases: i) during the first year (observational phase), patients with CAP hospitalized in the participating centers will be recorded to assess objective 1; ii) to achieve objective 2, at the beginning of the second year (quasi-experimental trial) the centers will be randomized into 2 groups of hospitals, one of them a control group and the other an intervention group. The intervention will consist in automatic reminders through pop-up windows in the computerized prescription software, reminding the clinician responsible for each patient of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment in patients with clinical stability.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients >18 years hospitalized for community-acquired pneumonia with a new infiltrateon chest X-ray and/or computerized tomography.
  • At least one compatible sign or symptom (fever, cough, expectoration, dyspnea, chestpain or crackles on auscultation)
  • Correctly treated with ≥ 3 days of antibiotic

Exclusion

Exclusion Criteria:

  • Intensive care unit admission during the first 5 days since hospital admission
  • Abscess or necrotizing pneumonia
  • Empyema or pleural effusion requiring drainage tube
  • Bronchiectasis
  • Cystic fibrosis
  • Active tuberculosis
  • Postobstructive pneumonia
  • Suspected bronchial aspiration
  • SARS-CoV-2 infection
  • Immunosuppression (congenital immunodeficiencies, HIV infection, solid organtransplantation, functional or anatomical asplenia, immunosuppressive treatment,active solid or haematological neoplasia [active treatment in the last 12 months],etc.)
  • Hospital acquired pneumonia
  • Concomitant extrapulmonary infection that requires antibiotic treatment for more than 5 days (eg myocarditis)
  • Confirmed diagnosis alternative to pneumonia (eg, lung cancer)

Study Design

Total Participants: 2000
Treatment Group(s): 1
Primary Treatment: Reminders to the assistant clinicians of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment community-acquired pneumonia
Phase:
Study Start date:
January 01, 2024
Estimated Completion Date:
August 31, 2025

Connect with a study center

  • University and Polytechnic Hospital La Fe

    Valencia,
    Spain

    Active - Recruiting

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