A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM

Inclusion Criteria:

• Stable euthyroid status (no known changes in thyroid function; stable hormonereplacement for at least 4 months) at screening

• Part A: body mass index (BMI) ≥27 kg/m^2 and ≤34.9 kg/m^2

• Part B: BMI ≥30 kg/m^2 to ≤39.9 kg/m^2, confirmed diagnosis of T2DM, and an HbA1c ≥7.5% to <10%

• Part B: Confirmed T2DM diagnosis

Exclusion Criteria:

• Parts A and B: has received an investigational agent within the last 30 days

• Part A: History of Type 1 or Type 2 diabetes

• Part B: History of Type 1 diabetes