Mg-containing Biodegradable Polymer Bone Repair Material

Inclusion Criteria:

1. Age ≥ 18 years old and ≤ 75 years old, regardless of gender;
2. Bone defect exists in one of the following anatomical positions, and bone grafting isrequired: Upper limb bones: humerus, ulna, radius, metacarpus, carpus, phalanges; Lower limb bones: femur, tibia, fibula, calcaneus, navicular bone, wedge bone, cuboidbone, metatarsal bone, talus and phalanges;
3. The maximum diameter of the expected or actual three-dimensional bone defect is ≥ 0.5cm and ≤ 6cm, and the defect is only one;
4. The bone defect site is expected to be fixed with non-degradable internal fixationsystem during operation;
5. Subjects or their legal representatives can understand the purpose of the study andshow sufficient compliance with the study protocol and sign the informed consent form.

Exclusion Criteria:

1. The blood glucose control is unstable and cannot meet the operation conditions;
2. Severe coagulation dysfunction (PT or APTT ≥ 2 times the upper limit of normal value);
3. History of arterial thrombosis attack (such as stroke, angina pectoris, acutemyocardial infarction, etc.) or NYHA grade ≥ III within 3 months before enrollment;
4. Oral or injection of sedative and hypnotic drugs or non-steroidal anti-inflammatorydrugs (except aspirin) every week within 3 months before enrollment;
5. He had received chemotherapy drugs or radiotherapy within 3 months before admission;
6. Cumulative oral or injection of corticosteroids or various growth factors for ≥ 14days within 1 month before enrollment;
7. Suffering from systemic infection or uncontrollable local infection, serious softtissue injury at the proposed operation site, serious vascular or nerve injury,malignant tumor, confirmed severe malnutrition or other important organ failure;
8. The limb to be operated on has osteofascial compartment syndrome;
9. Structural bone grafting is required;
10. Pregnant or lactating women;
11. Participate in clinical trials of other drugs or medical devices within one monthbefore enrollment;
12. For the benefit of the subject, the researcher believes that it should not participatein other situations of this clinical trial.