Intratendinous Genipin Injection in Horses With Tendon Injuries

Last updated: February 22, 2023
Sponsor: University of Zurich
Overall Status: Completed

Phase

3

Condition

Sprains

Tendon Injuries

Treatment

N/A

Clinical Study ID

NCT05755750
Genipin
  • All Genders

Study Summary

Our study is the first to use genipin, a naturally occurring collagen cross-linking agent, as a therapeutic agent to treat superficial digital flexor tendon (SDFT) injuries in horses. The promising approach of intratendinous genipin injection and tendon mechanical enhancement could be a viable alternative to current therapies for SDFT injuries.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • clinical and sonographic evidence of a tendon injury

Exclusion

Exclusion Criteria:

  • in the final analysis, only superficial digital flexor tendon injuries were included
  • if follow-up was less than 12 m due to euthanasia, death or other reasons, horses wereexcluded from the study

Study Design

Total Participants: 74
Study Start date:
June 28, 2016
Estimated Completion Date:
January 04, 2023

Study Description

Tendon injuries are a career limiting or ending condition in horses. Genipin (GP), an exogenous collagen crosslinker, provides ex-vivo tendon mechanical augmentation and excellent biosafety. The main objective of this study is to investigate treatment success of GP-induced collagen crosslinking in a clinical application in horses with superficial digital flexor tendon (SDFT) injuries. Horses with an AAEP (American Association of American Practitioners) lameness score > 0 and sonographically confirmed tendinopathy are treated with intratendinous GP injection (IGI) and controlled exercise. Minimal follow-up was set at 12 months. Outcome factors are lameness (AAEP lameness score), soundness, assessment of return to previous use, and re-injury. Additionally, adverse effects are recorded.

Connect with a study center

  • Equine surgery, Vetsuisse-Faculty, University of Zurich

    Zürich, ZH 8057
    Switzerland

    Site Not Available

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