The Role of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma in Immuno-oncology Era: SEVURO-CN Trial

Inclusion Criteria:

1. Core needle biopsy proven metastatic renal cell carcinoma - clear cell histologicsubtypes only acceptable.
2. Synchronous metastatic renal cell carcinoma with the primary tumor present in thekidney.
3. Patient must be willing to provide their human-derived materials.
4. Age ≥19.
5. Signed written informed consent obtained prior to any study specific procedures.
6. Patient must be willing and able to comply with the protocol.
7. Measurable disease as per RECIST v 1.1
8. Life expectancy of greater than 4 months.
9. Patients with more than one prognostic factor by the International Metastatic RCCDatabase Consortium (IMDC) criteria (intermediate- or poor-risk group).
10. Patients for which Nivolumab/Ipilimumab considered indicated according to therecommendations by the national health authorities. The prescription ofnivolumab/ipilimumab in the circumstances of the study is considered as a standardtreatment.
11. Karnofsky Performance status ≥70
12. Females with a negative serum pregnancy test unless childbearing potential can beotherwise excluded (postmenopausal, hysterectomy or oophorectomy) and not lactating.
13. Fertile women of childbearing potential (<2 years after last menstruation) and menmust use effective means of contraception (oral contraceptives, intrauterinecontraceptive device, barrier method of contraception in conjunction with spermicidaljelly or surgical sterilization).
14. The required laboratory values are as follows:

• Adequate bone marrow function (Absolute neutrophil count > 1500/mm3, platelets > 100 x 103/µl, hemoglobin > 10.0 g/dL.)
• International normalized ratio (INR) ≤ 1.2 x upper limit of normal (ULN)
• Adequate hepatic function (bilirubin ≤ 1.5 x ULN, ALAT ≤ 2.5 x ULN)
• Adequate kidney function (eGFR > 35 mL/min)

Exclusion Criteria:

1. Prior systemic treatment for mRCC
2. Major surgical procedure, open surgical biopsy, or significant traumatic injury within 28 days prior to enrollment
3. Other cancer within 5 years.
4. Clinically significant (i.e active) cardiovascular disease for example cerebrovascularaccidents (< 6 months before inclusion), myocardial infarction (< 6 months beforeinclusion), unstable angina, New York Heart Association (NYHA) grade II or greatercongestive heart failure.
5. No symptomatic brain metastasis requiring systemic corticosteroids (> 10 mg dailyprednisone equivalent)
6. Recent (within the 30 days prior to inclusion) treatment with another investigationaldrug or participation in another investigational study.
7. Any active or recent history of a known or suspected autoimmune disease or recenthistory of a condition that require systemic corticosteroids (> 10 mg daily prednisoneequivalent) or other immunosuppressive medications, excluding inhaled steroids andtopical steroids. Subjects with vitiligo or type I diabetes mellitus or residualhypothyroidism due to autoimmune thyroiditis only requiring hormone replacement,psoriasis not requiring systemic treatment are permitted to enroll.
8. Oral or i.v. antibiotics administered 14 days prior to initiation of systemic therapy.
9. Any positive test for hepatitis B- or C-Virus indicating acute or chronic infection.
10. Known hypersensitivity to monoclonal antibodies.
11. Known history of testing positive for human immunodeficiency virus (HIV) or knownacquired immunodeficiency syndrome (AIDS).
12. Patients disagreeing to provide their human-derived materials.
13. Patients not willing and able to comply with the protocol.
14. Vulnerable subjects (such as children, prisoners, pregnant women, mentally disabledpersons, or economically or educationally disadvantaged persons).
15. Patients who cannot read and understand the consent form. (illiterate, foreigners,etc.)