A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

Inclusion Criteria:

• Age ≥ 18

• Men with histologically confirmed localized prostate cancer undergoing activesurveillance.

• Inactive, defined as not meeting the national exercise guidelines for cancerpatients (<150 minutes/week of moderate or vigorous exercise)43 as assessed byremote activity and heart rate tracking for a 7-day period prior to study entry (general physical activity screening assessment via smart watch).

• Screening clearance by an MSK Exercise Physiologist (i.e., review of ECG)

• BMI <40 kg/m^2

• Cleared for exercise participation as per pre-screening clearance via the PhysicalActivity Readiness Questionnaire (PAR-Q+) (Appendix B)

Exclusion Criteria:

• Enrollment in any other program that may alter the impact of exercise on tumoroutcomes (e.g., weight loss program)

• Any neoadjuvant anticancer treatment of any kind for prostate cancer in the last 5years

• Any history of systemic anticancer therapy in the last 15 years

• Distant metastatic malignancy of any kind

• Any other condition or intercurrent illness that, in the opinion of theinvestigator, makes the subject a poor candidate for study participation