A Study to Assess the Safety and Efficacy of Ruxolitinib Cream in Participants With Genital Vitiligo

Inclusion Criteria:

• Clinical diagnosis of nonsegmental vitiligo with genital involvement

• At least ≥ 0.25% BSA of nonsegmental vitiligo in the genital area.

• Pigmented hair within some of the genital vitiligo areas.

• At least 1 genital target lesion that is ≥ 0.1% BSA that has a pigmented hair withinit.

• Vitiligo on areas of the body besides the genitals.

• Total body vitiligo area not exceeding 10% BSA.

• Willing to have genital photography conducted.

• Must agree to discontinue all agents used to treat vitiligo from screening throughthe final safety follow-up visit. Over-the-counter preparations deemed acceptable bythe investigator and camouflage makeups are permitted.

Exclusion Criteria:

• Other forms of vitiligo (eg, segmental) or other differential diagnosis of vitiligoor other skin depigmentation disorders.

• Prior or current use of depigmentation treatments (eg, monobenzone).

• Active or recurrent genital warts or herpes.

• Male participants with partners with known current/active cervical intraepithelialneoplasia or anal intraepithelial neoplasia.

• An active sexually transmitted disease, sexually transmitted infection, or otherskin disorder affecting the genital area (eg, scabies, fungal infection, molluscum).

• Had ≥ 3 laser hair removal treatments in an area to be treated for vitiligo.

• Any serious illness or medical, physical, or psychiatric condition(s) that, in theinvestigator's opinion, would interfere with full participation in the study orinterpretation of study data.

• Clinical laboratory test results outside of protocol defined ranges

• Pregnant or lactating participants, or those considering pregnancy during the periodof their study participation.