Metoclopramide in Upper Gastrointestinal Bleed

Last updated: July 9, 2023
Sponsor: Mercy Health System
Overall Status: Active - Recruiting

Phase

4

Condition

Gastric Ulcers

Ulcers

Gastrointestinal Diseases And Disorders

Treatment

Saline

Metoclopramide 10mg

Clinical Study ID

NCT05746377
#323
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this clinical trial is to test if metoclopramide can improve effectiveness of endoscopic intervention in upper gastrointestinal (GI) bleeds. The main questions the investigators hope to answer is

Does metoclopramide lessen the need for repeat endoscopy, interventional radiology intervention or surgery in cases of upper GI bleed?

Does metoclopramide improve visibility of the GI walls in cases of upper GI bleed?

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 and above
  • Admitted to ER or inpatient services at Javon Bea Hospital MercyHealth Riverside
  • Present with upper GI bleeding defined as fresh and bright red hematemesis,coffee-ground hematemesis or melena
  • Plan to undergo EGD within 24 hours since admission or since first symptoms
  • Calculated Glasgow-Blatchford score ≥ 2

Exclusion

Exclusion Criteria:

  • Failure to obtain informed consent
  • Known allergy to metoclopramide
  • Concurrent use of medications known to cause tardive dyskinesia (TD)/extrapyramidalsymptoms/neuroleptic malignant syndrome
  • History of TD or dystonic reaction to metoclopramide
  • Pheochromocytoma, catecholamine-releasing paragangliomas
  • Parkinson's Disease
  • Epilepsy
  • Pregnancy or lactation
  • Previous gastrectomy

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Saline
Phase: 4
Study Start date:
May 20, 2023
Estimated Completion Date:
June 30, 2024

Study Description

The purpose of the study is to see if giving metoclopramide prior to an endoscopy in cases of upper GI bleed can decrease the need for repeat endoscopy due to poor visibility. Metoclopramide stimulates stomach and intestine activity. It is used to treat nausea, vomiting and slow gut movement. The investigators are testing if metoclopramide's effect on stimulating stomach activity can lead to more effective emptying of blood from the stomach and upper intestines in upper GI bleeding so physicians conducting endoscopies can easily see the stomach and intestinal wall and treat the source of bleeding.

Connect with a study center

  • Javon Bea Hospital-Riverside - MercyHealth

    Rockford, Illinois 61114
    United States

    Active - Recruiting

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