Open-Label Extension Study to Evaluate the Long Term Safety and Efficacy of ESK-001 in Plaque Psoriasis

Last updated: October 24, 2025
Sponsor: Alumis Inc
Overall Status: Active - Not Recruiting

Phase

2

Condition

Skin Wounds

Warts

Psoriasis And Psoriatic Disorders

Treatment

ESK-001

Clinical Study ID

NCT05739435
ESK-001-007
  • Ages > 18
  • All Genders

Study Summary

This is a multi-center, open-label extension (OLE) study in patients with plaque psoriasis who have completed their participation in a previous plaque psoriasis study of ESK-001.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Must have completed a prior ESK-001 study

  • Men and Women must use highly effective methods of contraception for the entirety ofthe study

Exclusion

Exclusion Criteria:

  • Pregnancy

  • Received a prohibited concomitant medication

Study Design

Total Participants: 165
Treatment Group(s): 1
Primary Treatment: ESK-001
Phase: 2
Study Start date:
January 17, 2023
Estimated Completion Date:
December 30, 2026

Study Description

This study will consist of patients who have completed their participation in a previous plaque psoriasis study of ESK-001. Each patient will be assigned to receive ESK-001 at one of two open-label dose levels. Patients have the option to remain on study until ESK-001 is commercially available.

Connect with a study center

  • Investigator Site #2001

    Edmonton, Alberta T6G 1C3
    Canada

    Site Not Available

  • Investigator Site #2001

    Edmonton 5946768, Alberta 5883102 T6G 1C3
    Canada

    Site Not Available

  • Investigator Site # 2008

    Surrey, British Columbia V3V 0C6
    Canada

    Site Not Available

  • Investigator Site # 2008

    Surrey 6159905, British Columbia 5909050 V3V 0C6
    Canada

    Site Not Available

  • Investigator Site #2003

    Winnipeg, Manitoba R3M 3Z4
    Canada

    Site Not Available

  • Investigator Site #2003

    Winnipeg 6183235, Manitoba 6065171 R3M 3Z4
    Canada

    Site Not Available

  • Investigator Site #1033

    Norman, Oklahoma 73071
    Canada

    Site Not Available

  • Investigator Site #2006

    London, Ontario N6H 5L5
    Canada

    Site Not Available

  • Investigator Site # 2004

    Mississauga, Ontario L4Y 4C5
    Canada

    Site Not Available

  • Investigator Site # 2007

    North Bay, Ontario PiB 3Z7
    Canada

    Site Not Available

  • Investigator Site #2005

    Oakville, Ontario L6J 7W5
    Canada

    Site Not Available

  • Investigator Site #2009

    Toronto, Ontario M3H 5Y8
    Canada

    Site Not Available

  • Investigator Site # 2002

    Waterloo, Ontario N2J 1C4
    Canada

    Site Not Available

  • Investigator Site #2006

    London 6058560, Ontario 6093943 N6H 5L5
    Canada

    Site Not Available

  • Investigator Site # 2004

    Mississauga 6075357, Ontario 6093943 L4Y 4C5
    Canada

    Site Not Available

  • Investigator Site # 2007

    North Bay 6089426, Ontario 6093943 PiB 3Z7
    Canada

    Site Not Available

  • Investigator Site #2005

    Oakville 6092122, Ontario 6093943 L6J 7W5
    Canada

    Site Not Available

  • Investigator Site #2009

    Toronto 6167865, Ontario 6093943 M3H 5Y8
    Canada

    Site Not Available

  • Investigator Site # 2002

    Waterloo 6176823, Ontario 6093943 N2J 1C4
    Canada

    Site Not Available

  • Investigator Site # 2010

    Québec 6325494, Quebec 6115047 G1V 4X7
    Canada

    Site Not Available

  • Investigator Site # 2010

    Quebec, G1V 4X7
    Canada

    Site Not Available

  • Investigator Site # 1029

    Birmingham, Alabama 35205
    United States

    Site Not Available

  • Investigator Site # 1029

    Birmingham 4049979, Alabama 4829764 35205
    United States

    Site Not Available

  • Investigator Site #1001

    Phoenix, Arizona 85032
    United States

    Site Not Available

  • Investigator Site #1001

    Phoenix 5308655, Arizona 5551752 85032
    United States

    Site Not Available

  • Investigator Site # 1023

    Rogers, Arkansas 72758
    United States

    Site Not Available

  • Investigator Site # 1023

    Rogers 4128894, Arkansas 4099753 72758
    United States

    Site Not Available

  • Investigator Site #1021

    Encinitas, California 92024
    United States

    Site Not Available

  • Investigator Site #1018

    Los Angeles, California 90045
    United States

    Site Not Available

  • Investigator Site #1007

    Santa Monica, California 90404
    United States

    Site Not Available

  • Investigator Site #1002

    Sherman Oaks, California 91403
    United States

    Site Not Available

  • Investigator Site #1021

    Encinitas 5346646, California 5332921 92024
    United States

    Site Not Available

  • Investigator Site #1018

    Los Angeles 5368361, California 5332921 90045
    United States

    Site Not Available

  • Investigator Site #1007

    Santa Monica 5393212, California 5332921 90404
    United States

    Site Not Available

  • Investigator Site #1002

    Sherman Oaks 5395244, California 5332921 91403
    United States

    Site Not Available

  • Investigator site # 1030

    Fort Lauderdale, Florida 33308
    United States

    Site Not Available

  • Investigator Site #1025

    Hialeah, Florida 33012
    United States

    Site Not Available

  • Investigator site # 1028

    Miami, Florida 33175
    United States

    Site Not Available

  • Investigator Site # 1013

    Tampa, Florida 33614
    United States

    Site Not Available

  • Investigator site # 1030

    Fort Lauderdale 4155966, Florida 4155751 33308
    United States

    Site Not Available

  • Investigator Site #1025

    Hialeah 4158476, Florida 4155751 33012
    United States

    Site Not Available

  • Investigator site # 1028

    Miami 4164138, Florida 4155751 33175
    United States

    Site Not Available

  • Investigator Site # 1013

    Tampa 4174757, Florida 4155751 33614
    United States

    Site Not Available

  • Investigator Site #1035

    Macon, Georgia 31217
    United States

    Site Not Available

  • Investigator Site #1043

    Sandy Springs, Georgia 30328
    United States

    Site Not Available

  • Investigator Site #1035

    Macon 4207400, Georgia 4197000 31217
    United States

    Site Not Available

  • Investigator Site #1043

    Sandy Springs 4221333, Georgia 4197000 30328
    United States

    Site Not Available

  • Investigator Site #1005

    Rolling Meadows, Illinois 60008
    United States

    Site Not Available

  • Investigator Site #1005

    Rolling Meadows 4908052, Illinois 4896861 60008
    United States

    Site Not Available

  • Investigator Site # 1011

    Columbus, Indiana 47201
    United States

    Site Not Available

  • Investigator Site #1027

    South Bend, Indiana 46617
    United States

    Site Not Available

  • Investigator Site # 1011

    Columbus 4256038, Indiana 4921868 47201
    United States

    Site Not Available

  • Investigator Site #1027

    South Bend 4926563, Indiana 4921868 46617
    United States

    Site Not Available

  • Investigator SIte#1036

    Overland Park, Kansas 66210
    United States

    Site Not Available

  • Investigator SIte#1036

    Overland Park 4276873, Kansas 4273857 66210
    United States

    Site Not Available

  • Investigator Site #1017

    Owensboro, Kentucky 42301
    United States

    Site Not Available

  • Investigator Site #1017

    Owensboro 4303436, Kentucky 6254925 42301
    United States

    Site Not Available

  • Investigator Site #1026

    Rockville, Maryland 20850
    United States

    Site Not Available

  • Investigator Site #1026

    Rockville 4367175, Maryland 4361885 20850
    United States

    Site Not Available

  • Investigator Site #1010

    Clarkston, Michigan 48346
    United States

    Site Not Available

  • Investigator Site #1010

    Clarkston 4988997, Michigan 5001836 48346
    United States

    Site Not Available

  • Investigator Site #1031

    New Brighton, Minnesota 55112
    United States

    Site Not Available

  • Investigator Site #1031

    New Brighton 5039080, Minnesota 5037779 55112
    United States

    Site Not Available

  • Investigator Site # 1037

    Portsmouth, New Hampshire 03801
    United States

    Site Not Available

  • Investigator Site #1033

    Norman, Oklahoma 73071
    United States

    Site Not Available

  • Investigator Site #1033

    Norman 4543762, Oklahoma 4544379 73071
    United States

    Site Not Available

  • Investigator Site #1019

    Portland, Oregon 97223
    United States

    Site Not Available

  • Investigator Site #1019

    Portland 5746545, Oregon 5744337 97223
    United States

    Site Not Available

  • Investigator Site #1022

    Philadelphia, Pennsylvania 19103
    United States

    Site Not Available

  • Investigator Site #1022

    Philadelphia 4560349, Pennsylvania 6254927 19103
    United States

    Site Not Available

  • Investigator Site # 1012

    Rapid City, South Dakota 57702
    United States

    Site Not Available

  • Investigator Site # 1012

    Rapid City 5768233, South Dakota 5769223 57702
    United States

    Site Not Available

  • Investigator Site #1015

    Houston, Texas 77056
    United States

    Site Not Available

  • Investigator Site # 1006

    San Antonio, Texas 78213
    United States

    Site Not Available

  • Investigator Site #1015

    Houston 4699066, Texas 4736286 77056
    United States

    Site Not Available

  • Investigator Site # 1006

    San Antonio 4726206, Texas 4736286 78213
    United States

    Site Not Available

  • Investigator Site # 1041

    South Jordan, Utah 84095
    United States

    Site Not Available

  • Investigator Site # 1041

    South Jordan 5781770, Utah 5549030 84095
    United States

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.