Trigeminal Evoked Responses to Improve Rhizotomy

Last updated: November 15, 2024
Sponsor: University of Minnesota
Overall Status: Active - Recruiting

Phase

1

Condition

Trigeminal Neuralgia

Pain (Pediatric)

Pain

Treatment

TSEP + rhizotomy surgery

TSEPs recording only

Clinical Study ID

NCT05738096
Rhizotomy
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Trigeminal neuralgia (TGN) is a debilitating pain syndrome where electrical, shock- like jolts of pain affect the face. Trigeminal somatosensory evoked potentials (TSEPs) provide a promising modality for measuring the trigeminal sensory and nociceptive pathway by using peripheral stimulation of the trigeminal nerve (on the skin) and measuring low latency evoked potentials on the scalp (contralateral sensory cortex). While TSEPs have been measured in the past, it is not clear if implementing TSEPs into a routine neurosurgical rhizotomy procedure will be feasible. This is a prospective cohort study examining the feasibility of routinely performing TSEPs during rhizotomies for TGN.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults of 18 years or older

  • Scheduled to undergo percutaneous rhizotomy for facial pain

Exclusion

Exclusion Criteria:

  • For TGN: Facial pain of unclear origin (i.e. not clearly TGN pain) or Rhizotomyprocedure canceled

  • For Healthy control: Diagnosis or history of facial pain such as TMD or TGN, Historyof migraine, History of any functional pain disorder: fibromyalgia, IBS, CRPS orRecent chronic pain (within last month)

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: TSEP + rhizotomy surgery
Phase: 1
Study Start date:
November 01, 2023
Estimated Completion Date:
November 01, 2026

Connect with a study center

  • University of Minnesota

    Minneapolis, Minnesota 55455
    United States

    Active - Recruiting

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