Computerized Cognitive Training in Patients With Coronary Heart Disease and Mild Cognitive Impairment

Inclusion Criteria:

1. Over the age of 50;
2. Completion of more than 6 years of education;
3. Patients with coronary artery disease confirmed by coronary CT angiography or coronaryangiography;
4. Chief complaint of cognitive decline within 1 year;
5. The average score of any cognitive domain in processing speed, situational memory,working memory and visual space measured by the Basic Cognitive Ability Test (BCAT) isless than 1 SD compared with the normal population;
6. Agree to be randomized to cognitive function tests and cognitive training and be ableto receive follow-up as required.

Exclusion Criteria:

1. Previous definite diagnosis of dementia or brief Mental State Examination Scale (MMSE) < 24 points;
2. Cognitive dysfunction caused by cranial trauma, cranial tumor, Parkinson's disease,schizophrenia, Alzheimer's disease, anxiety and depression, and other neuropsychiatricdiseases;
3. Deaf and mute or other reasons cannot communicate normally;
4. Binge drinking or taking drugs (antihistamines, antipsychotics) that affect cognitivefunction;
5. Unable to master the use of cognitive training equipment after two 1-hour traininginstructions each time;
6. Patients who plan to undergo coronary intervention within 6 months or have undergonecoronary intervention within 1 month;
7. Severe liver and kidney function injury or critical condition, poor prognosis,estimated survival of less than 1 month.
8. Patients who had received general anesthesia within 3 months;
9. History of stroke and craniocerebral trauma within 6 months;
10. History of Parkinson's disease, schizophrenia, and epilepsy;
11. Prior neurosurgery or history of cranial tumors;
12. Nuclear magnetic examination contraindications: such as metal implants,claustrophobia, etc.;
13. patients living alone;
14. Patients with atrial fibrillation, structural heart disease, and infectiveendocarditis.