Platelet Rich Plasma as an Adjunct Therapy at the Time of Transvaginal Native Tissue Prolapse Surgery

Last updated: July 1, 2025
Sponsor: University of Alabama at Birmingham
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Genitourinary Prolapse

Treatment

Platelet rich plasma (PRP) Injection

Placebo

Clinical Study ID

NCT05731284
IRB-300009943
  • Ages > 18
  • Female

Study Summary

The purpose of the study is to evaluate the surgical outcomes of injecting platelet-rich plasma (PRP) into the vaginal tissue as an adjunct therapy at the time of prolapse surgery

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Desire surgical treatment via a transvaginal native tissue approach.

  • Completed child-bearing

Exclusion

Exclusion Criteria:

  • Unable to follow-up, not willing to, or unable to participate in the proposed study

  • Prior pelvic surgery within the past 12 months

  • Prior anterior/apical suspension procedures

  • Prior graft augmented prolapse surgery

  • Pelvic/abdominal radiation

  • Pelvic mass

  • History of solid organ malignancy

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Platelet rich plasma (PRP) Injection
Phase:
Study Start date:
July 01, 2023
Estimated Completion Date:
December 31, 2028

Study Description

Platelet rich plasma (PRP) is an autologous product with high levels of platelets which are concentrated with bioactive growth factors responsible for accelerating tissue healing by stimulating the number of reparative cells to create collagen production, angiogenesis and neurogenesis. The overarching goal is to evaluate the effectiveness and safety of the adjunct application of PRP in the fibromuscular connective tissue (the site of anterior tissue plication) at the time of anterior colporrhaphy (the site of highest recurrence risk) in women undergoing native tissue vaginal prolapse repair, to promote tissue healing and regeneration, thus to improve surgical outcomes.

Connect with a study center

  • University of Alabama at Birmingham

    Birmingham, Alabama 35249
    United States

    Site Not Available

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