Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study

Last updated: December 6, 2023
Sponsor: Chinese University of Hong Kong
Overall Status: Active - Recruiting

Phase

N/A

Condition

Mild Cognitive Impairment

Memory Problems

Memory Loss

Treatment

Ageing

Clinical Study ID

NCT05728801
2019.078
  • Ages 60-95
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This is a prospective follow-up study conducted at the Department of Psychiatry, The Chinese University of Hong Kong. The participants, including high-performing elderly (SuperAgers), normal ageing elderly and neurocognitive disorder (NCD) patients will be re-invited from our previous cohort (2013-2014) (N=488).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • SuperAgers are determined by the scores of global cognitive function. This ensuredthat the participants are divided by a measure relevant to the current study withoutdirectly biasing the results toward the domain of interest;
  • Normal aging: the cases with the scores of cognitive performance within 1.5 standarddeviation (SD) of age and education matched normative values derived from our cohortstudy, of which presented with HK MoCA score greater than 26 and CDR score equal to 0;
  • NCD patients are defined as: evidence of modest decline in one or more cognitivedomains, which is set as ≥ 1.5 SD below the age- and education-adjusted normativescores; no interference with independence in everyday activities; and no comorbidmajor psychiatric disorders.

Exclusion

Exclusion Criteria:

  • History of bipolar disorders or psychosis;
  • History of major neurological deficits including stroke, transient ischemic attack ortraumatic brain injury;
  • Comorbidities with depressive symptoms.

Study Design

Total Participants: 400
Treatment Group(s): 1
Primary Treatment: Ageing
Phase:
Study Start date:
June 01, 2022
Estimated Completion Date:
December 01, 2024

Study Description

Objectives: This study aims to investigate the cognitive changes in older adults with different cognitive statuses.

Connect with a study center

  • Tai Po Hospital

    Hong Kong,
    Hong Kong

    Active - Recruiting

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