The Effectiveness of Epidermal Growth Factor Serum in Improve Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles.

Last updated: July 14, 2025
Sponsor: Institute of Dermatology, Thailand
Overall Status: Completed

Phase

N/A

Condition

Aging

Treatment

Epidermal Growth Factor

Clinical Study ID

NCT05724589
008/2565
  • Ages 40-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

EGF is a polypeptide that promotes cell differentiation and collagen production while decreasing melanin production. This study is designed to study its effectiveness in improving the texture and appearance of facial skin after daily topical application. We hypothesized that EGF would improve facial skin hydration, elasticity, pigmentation, and wrinkles.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Thai

  • Mild to moderate facial skin condition, as measured by 1-2 points on thehyperpigmentation status scale or 2-3 points on the wrinkle severity grading scale.

Exclusion

Exclusion Criteria:

  • Use of lotions or skin care products containing ingredients such as vitamin A/C,hydroquinone, or anti-aging agents.

  • Sunbathing

  • Hypersensitivity to serum components

  • Pregnancy and breast-feeding

  • Active skin diseases such as eczema or atopic dermatitis at the application site

Study Design

Total Participants: 28
Treatment Group(s): 1
Primary Treatment: Epidermal Growth Factor
Phase:
Study Start date:
January 30, 2023
Estimated Completion Date:
December 12, 2024

Study Description

All patients gave written informed consent for epidermal growth factor serum application on the face. The pilot study enrolls thirty patients compared to pre and post-serum used to evaluate facial skin hydration, transepidermal water loss, elasticity, pigmentation, and wrinkles measured by corneometer, tewameter, cutometer, visioscan, and mexameter respectively on day 0, then 8, 12, and 16 weeks. The study evaluates subject satisfaction and side effects after serum application as secondary outcomes.

Connect with a study center

  • Institute of Dermatology

    Bangkok, 10400
    Thailand

    Site Not Available

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