L-Citrulline and Endothelial Function

Last updated: September 16, 2024
Sponsor: University of Oklahoma
Overall Status: Active - Recruiting

Phase

1

Condition

Aging

Treatment

L-Citrulline, capsule

L-Citrulline, 2500 mg capsule

Clinical Study ID

NCT05722860
15485
  • Ages 18-90
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The effect of L-Citrulline is well studied in relation to muscle strength, exhaustion, exercise performance, and endothelial function in health and disease. This study will extend current body of knowledge and will investigate the effect of L-Citrulline on brain vascular function.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 21-45 and ≥55-90 years of age

  • Adequate hearing and visual acuity to participate in the examinations

  • Ability to read and write in English

  • Competence to provide informed consent

Exclusion

Exclusion Criteria:

  • Active CNS disease including multiple sclerosis, uncontrolled seizures, active braincancer

  • Cerebrovascular accident other than TIA within 60 days prior to Visit 0

  • Major psychiatric disease, including major depression not currently controlled onmedications, alcohol or drug abuse

  • Treatment with other Citrulline enhancers (L-Arginine, L-Citrulline Malate) within 4weeks prior to Visit 0

  • Any other medical condition which, in the opinion of investigator, would render thepatient inappropriate or too unstable to complete the study protocol

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: L-Citrulline, capsule
Phase: 1
Study Start date:
January 03, 2024
Estimated Completion Date:
December 28, 2024

Study Description

Endothelial function is associated with nitric oxide (NO) availability for vasodilation, blood pressure and blood flow regulation, and vascular health. A large body of evidence demonstrates that aging is associated with a decrease in bioavailability of NO, with more pronounced decrease in sedentary individuals. NO can be produced via the NO synthase (NOS) enzymes, which catalyze the conversion of L-Arginine - a semi-essential amino acid found in fish, nuts and legumes amongst others - to L-Citrulline and produce NO as an endproduct. While the effect of L-Citrulline is extensively studied in relation to muscle strength, exhaustion, exercise performance, as well as on endothelial function in healthy and diseased individuals (including obese and those with heart failure), the effect of L-Citrulline on brain vascular function is not well studied.

Connect with a study center

  • Andriy Yabluchanskiy

    Oklahoma City, Oklahoma 73117
    United States

    Active - Recruiting

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